The impact of plasma zinc status on the severity of prostate cancer disease
Purpose: The severity of prostate cancer (PCa), which determines the disease progression, is theorized to be a function of zinc status. Hence, this study was structured to determine the impact of zinc status on the severity and progression of PCa disease. Materials and Methods: This was a descriptiv...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2019-05-01
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| Series: | Investigative and Clinical Urology |
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| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-162.pdf |
| _version_ | 1818158407414185984 |
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| author | Victor C. Wakwe Ehimen. P. Odum Collins Amadi |
| author_facet | Victor C. Wakwe Ehimen. P. Odum Collins Amadi |
| author_sort | Victor C. Wakwe |
| collection | DOAJ |
| description | Purpose: The severity of prostate cancer (PCa), which determines the disease progression, is theorized to be a function of zinc status. Hence, this study was structured to determine the impact of zinc status on the severity and progression of PCa disease. Materials and Methods: This was a descriptive cross-sectional study of 220 histologically-confirmed PCa patients and 220 age-matched controls, conducted prospectively in a Nigerian tertiary hospital. Plasma zinc, prostate-specific antigen, creatinine, fasting glucose, and estimated glomerular filtration rate were determined for both study groups. The International Society of Urological Pathology (ISUP) grades and the American Joint Committee on Cancer clinical staging were employed as indices for PCa severity (grade) and progression (stage) respectively. Results: The PCa patients had markedly reduced plasma zinc status compared to controls (cases: 9.42±3.02 µmol/L versus controls: 15.23±4.47 µmol/L; p<0.001). Low zinc status was more pronounced within the severe grade and advanced PCa disease subgroups (p<0.001). Inverse relationships existed between zinc status and ISUP grades among the entire PCa patient (p<0.001) and the categorized PCa grade and stage subgroups (p<0.001). Low zinc status had significant impact of predicting severe (crude=odds ratio [OR], 8.714; p<0.001; age-adjusted=OR, 11.152; p<0.001) and advanced (crude=OR, 17.160; p<0.001; age-adjusted=OR, 18.927; p<0.001) PCa disease. Conclusions: This study suggests that low plasma zinc status is associated with severe grade and advanced PCa disease. However, further well-designed studies with large sample sizes are warranted to confirm these associations. |
| first_indexed | 2024-12-11T15:29:36Z |
| format | Article |
| id | doaj.art-e994be5f4c434c1584f542eedddc4872 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-12-11T15:29:36Z |
| publishDate | 2019-05-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-e994be5f4c434c1584f542eedddc48722022-12-22T01:00:07ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2019-05-0160316216810.4111/icu.2019.60.3.162The impact of plasma zinc status on the severity of prostate cancer diseaseVictor C. Wakwe0Ehimen. P. Odum1Collins Amadi2Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.Purpose: The severity of prostate cancer (PCa), which determines the disease progression, is theorized to be a function of zinc status. Hence, this study was structured to determine the impact of zinc status on the severity and progression of PCa disease. Materials and Methods: This was a descriptive cross-sectional study of 220 histologically-confirmed PCa patients and 220 age-matched controls, conducted prospectively in a Nigerian tertiary hospital. Plasma zinc, prostate-specific antigen, creatinine, fasting glucose, and estimated glomerular filtration rate were determined for both study groups. The International Society of Urological Pathology (ISUP) grades and the American Joint Committee on Cancer clinical staging were employed as indices for PCa severity (grade) and progression (stage) respectively. Results: The PCa patients had markedly reduced plasma zinc status compared to controls (cases: 9.42±3.02 µmol/L versus controls: 15.23±4.47 µmol/L; p<0.001). Low zinc status was more pronounced within the severe grade and advanced PCa disease subgroups (p<0.001). Inverse relationships existed between zinc status and ISUP grades among the entire PCa patient (p<0.001) and the categorized PCa grade and stage subgroups (p<0.001). Low zinc status had significant impact of predicting severe (crude=odds ratio [OR], 8.714; p<0.001; age-adjusted=OR, 11.152; p<0.001) and advanced (crude=OR, 17.160; p<0.001; age-adjusted=OR, 18.927; p<0.001) PCa disease. Conclusions: This study suggests that low plasma zinc status is associated with severe grade and advanced PCa disease. However, further well-designed studies with large sample sizes are warranted to confirm these associations.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-162.pdfNeoplasm gradingNeoplasm stagingProstatic neoplasmsZinc |
| spellingShingle | Victor C. Wakwe Ehimen. P. Odum Collins Amadi The impact of plasma zinc status on the severity of prostate cancer disease Investigative and Clinical Urology Neoplasm grading Neoplasm staging Prostatic neoplasms Zinc |
| title | The impact of plasma zinc status on the severity of prostate cancer disease |
| title_full | The impact of plasma zinc status on the severity of prostate cancer disease |
| title_fullStr | The impact of plasma zinc status on the severity of prostate cancer disease |
| title_full_unstemmed | The impact of plasma zinc status on the severity of prostate cancer disease |
| title_short | The impact of plasma zinc status on the severity of prostate cancer disease |
| title_sort | impact of plasma zinc status on the severity of prostate cancer disease |
| topic | Neoplasm grading Neoplasm staging Prostatic neoplasms Zinc |
| url | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-162.pdf |
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