Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression
Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA can act like oncoviruses, entering the cells of vu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12246 |
| _version_ | 1797510029470859264 |
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| author | Ludmila Alekseeva Nadezhda Mironova |
| author_facet | Ludmila Alekseeva Nadezhda Mironova |
| author_sort | Ludmila Alekseeva |
| collection | DOAJ |
| description | Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA can act like oncoviruses, entering the cells of vulnerable organs, transforming them and forming metastatic nodes. Another source of cfDNA is immune cells, including neutrophils that generate neutrophil extracellular traps (NETs). Despite the potential eliminative effect of NETs on tumors, in some cases, their excessive generation provokes tumor growth as well as invasion. Considering both possible pathological contributions of cfDNA, as an agent of oncotransformation and the main component of NETs, the study of deoxyribonucleases (DNases) as anticancer and antimetastatic agents is important and promising. This review considers the pathological role of cfDNA in cancer development and the role of DNases as agents to prevent and/or prohibit tumor progression and the development of metastases. |
| first_indexed | 2024-03-10T05:27:04Z |
| format | Article |
| id | doaj.art-e9962a930f0546f3a17937210578e9fe |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:27:04Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e9962a930f0546f3a17937210578e9fe2023-11-22T23:39:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221224610.3390/ijms222212246Role of Cell-Free DNA and Deoxyribonucleases in Tumor ProgressionLudmila Alekseeva0Nadezhda Mironova1Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrentiev Ave., 8, 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrentiev Ave., 8, 630090 Novosibirsk, RussiaMany studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA can act like oncoviruses, entering the cells of vulnerable organs, transforming them and forming metastatic nodes. Another source of cfDNA is immune cells, including neutrophils that generate neutrophil extracellular traps (NETs). Despite the potential eliminative effect of NETs on tumors, in some cases, their excessive generation provokes tumor growth as well as invasion. Considering both possible pathological contributions of cfDNA, as an agent of oncotransformation and the main component of NETs, the study of deoxyribonucleases (DNases) as anticancer and antimetastatic agents is important and promising. This review considers the pathological role of cfDNA in cancer development and the role of DNases as agents to prevent and/or prohibit tumor progression and the development of metastases.https://www.mdpi.com/1422-0067/22/22/12246circulating cell-free DNAneutrophil extracellular traps (NETs)tumor and metastasis developmentDNases |
| spellingShingle | Ludmila Alekseeva Nadezhda Mironova Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression International Journal of Molecular Sciences circulating cell-free DNA neutrophil extracellular traps (NETs) tumor and metastasis development DNases |
| title | Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression |
| title_full | Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression |
| title_fullStr | Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression |
| title_full_unstemmed | Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression |
| title_short | Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression |
| title_sort | role of cell free dna and deoxyribonucleases in tumor progression |
| topic | circulating cell-free DNA neutrophil extracellular traps (NETs) tumor and metastasis development DNases |
| url | https://www.mdpi.com/1422-0067/22/22/12246 |
| work_keys_str_mv | AT ludmilaalekseeva roleofcellfreednaanddeoxyribonucleasesintumorprogression AT nadezhdamironova roleofcellfreednaanddeoxyribonucleasesintumorprogression |