BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model

BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model

Duchenne Muscular Dystrophy (DMD) is an X-linked lethal muscle wasting disease characterized by muscle fiber degeneration and necrosis. The progressive pathology of DMD can be explained by an insufficient regenerative response resulting in fibrosis and adipose tissue formation. BMPs are known to inh...

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Bibliographic Details
Main Authors: SongTing Shi, Willem M.H. Hoogaars, David J.J. de Gorter, Sandra H. van Heiningen, Herbert Y. Lin, Charles C. Hong, Dwi U. Kemaladewi, Annemieke Aartsma-Rus, Peter ten Dijke, Peter A.C. 't Hoen
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
DMD
BMP signaling
Myogenic differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003347

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