Autocrine IFNγ controls the regulatory function of lymphoproliferative double negative T cells.

Autocrine IFNγ controls the regulatory function of lymphoproliferative double negative T cells.

TCRαβ(+) CD4(-)CD8(-)NK(-) double negative T cells (DN T cells) can act as regulatory T cells to inhibit allograft rejection and autoimmunity. Their role in graft-versus-host disease and mechanisms of suppression remain elusive. In this study, we demonstrate that DN T cells can inhibit CD4(+) T cell...

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Bibliographic Details
Main Authors: Stephen C Juvet, Mei Han, Ramesh Vanama, Betty Joe, Edward Y Kim, Fei Linda Zhao, Caroline Jeon, Oyedele Adeyi, Li Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3471870?pdf=render

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