Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer
Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IGF-1) is involved in a number of patho-physiological processes, as well as in the development of different types of solid tumors, including breast cancer (BC). Preclinical and clinical data showed that...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.641449/full |
| _version_ | 1818416534142320640 |
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| author | Anna Ianza Marianna Sirico Marianna Sirico Ottavia Bernocchi Daniele Generali Daniele Generali Daniele Generali |
| author_facet | Anna Ianza Marianna Sirico Marianna Sirico Ottavia Bernocchi Daniele Generali Daniele Generali Daniele Generali |
| author_sort | Anna Ianza |
| collection | DOAJ |
| description | Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IGF-1) is involved in a number of patho-physiological processes, as well as in the development of different types of solid tumors, including breast cancer (BC). Preclinical and clinical data showed that IGF-1 receptor (R) is overexpressed and hyper-phosphorylated in several subtypes of BCs. The central implications of this pathway in tumor cell proliferation and metastasis make it an important therapeutic target. Moreover, the IGF-1 axis has shown strong interconnection with estrogen regulation and endocrine therapy, suggesting a possible solution to anti-estrogen resistance. IGF-1R might also interfere with other pivotal therapeutic strategies, such as anti HER2 treatments and mTOR inhibitors; several clinical trials are ongoing evaluating the role of IGF-1R inhibition in modulating resistance mechanisms to target therapies. Our aim is to offer an overview of the most recent and significant field of application of IGF-1 inhibitors and relevant therapeutic strategies, weighing their possible future impact on clinical practice. |
| first_indexed | 2024-12-14T11:52:25Z |
| format | Article |
| id | doaj.art-e99748a7357c44b285802c60b16681ef |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T11:52:25Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e99748a7357c44b285802c60b16681ef2022-12-21T23:02:15ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.641449641449Role of the IGF-1 Axis in Overcoming Resistance in Breast CancerAnna Ianza0Marianna Sirico1Marianna Sirico2Ottavia Bernocchi3Daniele Generali4Daniele Generali5Daniele Generali6Department of Medical, Surgery and Health Sciences, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, ItalyDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United KingdomBreast Cancer Unit and Translational Research Unit, ASST Cremona, Cremona, ItalyDepartment of Medical, Surgery and Health Sciences, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, ItalyDepartment of Medical, Surgery and Health Sciences, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, ItalyBreast Cancer Unit and Translational Research Unit, ASST Cremona, Cremona, ItalyDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, ItalyOver the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IGF-1) is involved in a number of patho-physiological processes, as well as in the development of different types of solid tumors, including breast cancer (BC). Preclinical and clinical data showed that IGF-1 receptor (R) is overexpressed and hyper-phosphorylated in several subtypes of BCs. The central implications of this pathway in tumor cell proliferation and metastasis make it an important therapeutic target. Moreover, the IGF-1 axis has shown strong interconnection with estrogen regulation and endocrine therapy, suggesting a possible solution to anti-estrogen resistance. IGF-1R might also interfere with other pivotal therapeutic strategies, such as anti HER2 treatments and mTOR inhibitors; several clinical trials are ongoing evaluating the role of IGF-1R inhibition in modulating resistance mechanisms to target therapies. Our aim is to offer an overview of the most recent and significant field of application of IGF-1 inhibitors and relevant therapeutic strategies, weighing their possible future impact on clinical practice.https://www.frontiersin.org/articles/10.3389/fcell.2021.641449/fullIGF1IGF-1Rclinical trialtherapy resistancebreast cancer |
| spellingShingle | Anna Ianza Marianna Sirico Marianna Sirico Ottavia Bernocchi Daniele Generali Daniele Generali Daniele Generali Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer Frontiers in Cell and Developmental Biology IGF1 IGF-1R clinical trial therapy resistance breast cancer |
| title | Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer |
| title_full | Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer |
| title_fullStr | Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer |
| title_full_unstemmed | Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer |
| title_short | Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer |
| title_sort | role of the igf 1 axis in overcoming resistance in breast cancer |
| topic | IGF1 IGF-1R clinical trial therapy resistance breast cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.641449/full |
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