EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes.

EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes.

Viruses suppress immune recognition through diverse mechanisms. Epstein-Barr Virus (EBV) establishes latent infection in memory B-lymphocytes and B-cell malignancies where it impacts B-cell immune function. We show here that EBV primary infection of naïve B-cells results in a robust down-regulation...

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Bibliographic Details
Main Authors: Chenhe Su, Fang Lu, Samantha S Soldan, R Jason Lamontagne, Hsin-Yao Tang, Giorgia Napoletani, Paul J Farrell, Italo Tempera, Andrew V Kossenkov, Paul M Lieberman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009834

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