The effect of antidepressant treatment on white matter integrity in Major Depression
Introduction White matter abnormalities have been identified in major depressive disorder (MDD). Although several diffusion tensor imaging studies found decreased fractional anisotropy (FA) in MDD, the effect of antidepressants (AD) treatment on white matter integrity has been insufficiently studie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822005557/type/journal_article |
| _version_ | 1797616679998455808 |
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| author | S. Tourjman S. Potvin R. Milan E. Kouassi D. Luck |
| author_facet | S. Tourjman S. Potvin R. Milan E. Kouassi D. Luck |
| author_sort | S. Tourjman |
| collection | DOAJ |
| description |
Introduction
White matter abnormalities have been identified in major depressive disorder (MDD). Although several diffusion tensor imaging studies found decreased fractional anisotropy (FA) in MDD, the effect of antidepressants (AD) treatment on white matter integrity has been insufficiently studied.
Objectives
We sought to examine the effect of AD treatment of MDD on white matter, using DTI, in responders compared to nonresponders.
Methods
We included 25 individuals with MDD (HAMD >/=20) without inflammatory, unstable medical/neurological conditions or prolonged duration (> 1 year),or AD or anti-inflammatory treatment >/=1 week preceding first evaluation. Evaluation before treatment and at 16 weeks included depression rating scales, a cognitive battery, inflammatory markers and MRI. Desvenlafaxine was initiated at 50mg with a possible increase to 100mg at 8 weeks.
Results
Changes included: increased volume in responders in the right Inferior Fronto-Occipital fasciculus (p=0.0315) and Superior Longitudinal Fasciculus part 3 (p=0.0050); in remitters in the right Inferior Fronto-Occipital fasciculus (p=0.0359) and Superior Longitudinal Fasciculus part 2 (p<0.05) and 3 (p=0.0481); decreased volume in responders in the left Superior Longitudinal Fasciculus part 1 (p=0.0147) and left Corona Radiata(p<0.05); and in remitters in the left Superior Longitudinal Fasciculus part 1 (p=0.0109) and the Corpus Callosum part 5 (p<0.05); decreased FA in the right Cortico Spinal Tract in remitters (p=0.0175) and responders (p=0.0272), and an increase in FA in the left Uncinate Fasciculus in nonremitters (p=0.0493). These results lose significance following Bonferroni correction.
Conclusions
Overall, AD treatment of MDD was not associated with significant changes in FA, whole brain, or specific tract volume in this study.
Disclosure
This research was funded by Pfizer Canada.
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| first_indexed | 2024-03-11T07:44:44Z |
| format | Article |
| id | doaj.art-e99b03c82956422f9bfabb7951be68d0 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:44:44Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-e99b03c82956422f9bfabb7951be68d02023-11-17T05:08:02ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S213S21310.1192/j.eurpsy.2022.555The effect of antidepressant treatment on white matter integrity in Major DepressionS. Tourjman0S. Potvin1R. Milan2E. Kouassi3D. Luck4Institut Universitaire en Santé Mentale de Montréal, Psychiatry, Montréal, CanadaInstitut Universitaire en Santé Mentale de Montréal, Psychiatry, Montréal, CanadaMcGill University, Medicine, Montréal, CanadaMcGill University, Medicine, Montréal, CanadaMcGill University, Medicine, Montréal, Canada Introduction White matter abnormalities have been identified in major depressive disorder (MDD). Although several diffusion tensor imaging studies found decreased fractional anisotropy (FA) in MDD, the effect of antidepressants (AD) treatment on white matter integrity has been insufficiently studied. Objectives We sought to examine the effect of AD treatment of MDD on white matter, using DTI, in responders compared to nonresponders. Methods We included 25 individuals with MDD (HAMD >/=20) without inflammatory, unstable medical/neurological conditions or prolonged duration (> 1 year),or AD or anti-inflammatory treatment >/=1 week preceding first evaluation. Evaluation before treatment and at 16 weeks included depression rating scales, a cognitive battery, inflammatory markers and MRI. Desvenlafaxine was initiated at 50mg with a possible increase to 100mg at 8 weeks. Results Changes included: increased volume in responders in the right Inferior Fronto-Occipital fasciculus (p=0.0315) and Superior Longitudinal Fasciculus part 3 (p=0.0050); in remitters in the right Inferior Fronto-Occipital fasciculus (p=0.0359) and Superior Longitudinal Fasciculus part 2 (p<0.05) and 3 (p=0.0481); decreased volume in responders in the left Superior Longitudinal Fasciculus part 1 (p=0.0147) and left Corona Radiata(p<0.05); and in remitters in the left Superior Longitudinal Fasciculus part 1 (p=0.0109) and the Corpus Callosum part 5 (p<0.05); decreased FA in the right Cortico Spinal Tract in remitters (p=0.0175) and responders (p=0.0272), and an increase in FA in the left Uncinate Fasciculus in nonremitters (p=0.0493). These results lose significance following Bonferroni correction. Conclusions Overall, AD treatment of MDD was not associated with significant changes in FA, whole brain, or specific tract volume in this study. Disclosure This research was funded by Pfizer Canada. https://www.cambridge.org/core/product/identifier/S0924933822005557/type/journal_articleNeuroimagingDepressionantidepressantDTI |
| spellingShingle | S. Tourjman S. Potvin R. Milan E. Kouassi D. Luck The effect of antidepressant treatment on white matter integrity in Major Depression European Psychiatry Neuroimaging Depression antidepressant DTI |
| title | The effect of antidepressant treatment on white matter integrity in Major Depression |
| title_full | The effect of antidepressant treatment on white matter integrity in Major Depression |
| title_fullStr | The effect of antidepressant treatment on white matter integrity in Major Depression |
| title_full_unstemmed | The effect of antidepressant treatment on white matter integrity in Major Depression |
| title_short | The effect of antidepressant treatment on white matter integrity in Major Depression |
| title_sort | effect of antidepressant treatment on white matter integrity in major depression |
| topic | Neuroimaging Depression antidepressant DTI |
| url | https://www.cambridge.org/core/product/identifier/S0924933822005557/type/journal_article |
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