Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management
We investigated the impact of three marriageable actions: normal-to-carrier, carrier-to-normal, and carrier-to-carrier marriages on thalassemia and carrier populations. The well-known strategy is limiting the carrier-to-carrier marriage to reduce the thalassemia population. Thus, the other two marri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Thalassemia Reports |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2039-4365/12/3/16 |
| _version_ | 1797481951850921984 |
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| author | Sehjeong Kim Hamda AlDhaheri So-Yeun Kim |
| author_facet | Sehjeong Kim Hamda AlDhaheri So-Yeun Kim |
| author_sort | Sehjeong Kim |
| collection | DOAJ |
| description | We investigated the impact of three marriageable actions: normal-to-carrier, carrier-to-normal, and carrier-to-carrier marriages on thalassemia and carrier populations. The well-known strategy is limiting the carrier-to-carrier marriage to reduce the thalassemia population. Thus, the other two marriageable actions were often ignored. Other than a simple explanation of their genetic consequences, their important aspect in the thalassemia inheritance mechanism has never been studied at the population level. Moreover, there is no mathematical model investigating problem of interest for blood disorders at the population level. Hence, we developed a mathematical model to examine the possibility of eradication/reduction of thalassemia and carrier populations through each of the three marriageable actions in the long-term. We conducted computer simulations with the demographic data of the United Arab Emirates in which high thalassemia carrier prevalence is identified. We found that promoting more carrier-to-normal marriage will eventually have the same effects on marriage reconsideration for carrier-carrier couples, contributing to the reduction of the carrier population in the long-term. Interestingly, the normal-to-carrier marriage does not necessarily have a similar effect on thalassemia and carrier populations as that of the carrier-to-normal marriage. Thus, the two marriageable actions should be distinguished and also seriously considered in education and public awareness campaigns for thalassemia. |
| first_indexed | 2024-03-09T22:21:40Z |
| format | Article |
| id | doaj.art-e99d4c8c0cbc4a85934916d6f9183c0b |
| institution | Directory Open Access Journal |
| issn | 2039-4365 |
| language | English |
| last_indexed | 2024-03-09T22:21:40Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Thalassemia Reports |
| spelling | doaj.art-e99d4c8c0cbc4a85934916d6f9183c0b2023-11-23T19:14:24ZengMDPI AGThalassemia Reports2039-43652022-09-0112310512210.3390/thalassrep12030016Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population ManagementSehjeong Kim0Hamda AlDhaheri1So-Yeun Kim2Department of Mathematical Sciences and Institute of Public Health, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Mathematical Sciences and Institute of Public Health, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Business Administration, Seoul National University of Science & Technology, Seoul 01811, KoreaWe investigated the impact of three marriageable actions: normal-to-carrier, carrier-to-normal, and carrier-to-carrier marriages on thalassemia and carrier populations. The well-known strategy is limiting the carrier-to-carrier marriage to reduce the thalassemia population. Thus, the other two marriageable actions were often ignored. Other than a simple explanation of their genetic consequences, their important aspect in the thalassemia inheritance mechanism has never been studied at the population level. Moreover, there is no mathematical model investigating problem of interest for blood disorders at the population level. Hence, we developed a mathematical model to examine the possibility of eradication/reduction of thalassemia and carrier populations through each of the three marriageable actions in the long-term. We conducted computer simulations with the demographic data of the United Arab Emirates in which high thalassemia carrier prevalence is identified. We found that promoting more carrier-to-normal marriage will eventually have the same effects on marriage reconsideration for carrier-carrier couples, contributing to the reduction of the carrier population in the long-term. Interestingly, the normal-to-carrier marriage does not necessarily have a similar effect on thalassemia and carrier populations as that of the carrier-to-normal marriage. Thus, the two marriageable actions should be distinguished and also seriously considered in education and public awareness campaigns for thalassemia.https://www.mdpi.com/2039-4365/12/3/16thalassemiathree marriageable actionspublic healthmathematical modeling |
| spellingShingle | Sehjeong Kim Hamda AlDhaheri So-Yeun Kim Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management Thalassemia Reports thalassemia three marriageable actions public health mathematical modeling |
| title | Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management |
| title_full | Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management |
| title_fullStr | Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management |
| title_full_unstemmed | Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management |
| title_short | Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management |
| title_sort | going back to fundamentals three marriageable actions for thalassemia and carrier population management |
| topic | thalassemia three marriageable actions public health mathematical modeling |
| url | https://www.mdpi.com/2039-4365/12/3/16 |
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