Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis remain unanswered. Key open questions are (1) whe...

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Bibliographic Details
Main Authors: Jakob Malsy, Andrea C Alvarado, Joseph O Lamontagne, Karin Strittmatter, Alexander G Marneros
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
inflammasome
choroidal neovascularization
neovascular age-related macular degeneration
complement
NLRP3
caspase-1
Online Access:https://elifesciences.org/articles/60194

Internet

https://elifesciences.org/articles/60194

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