Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis remain unanswered. Key open questions are (1) whe...

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Bibliographic Details
Main Authors:	Jakob Malsy, Andrea C Alvarado, Joseph O Lamontagne, Karin Strittmatter, Alexander G Marneros
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-12-01
Series:	eLife
Subjects:	inflammasome choroidal neovascularization neovascular age-related macular degeneration complement NLRP3 caspase-1
Online Access:	https://elifesciences.org/articles/60194

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