Cerebrospinal Fluid Protein Concentrations in Hydrocephalus
CSF protein levels are altered in neurological disorders, such as hydrocephalus of different etiologies. In this retrospective observational study, we analyzed cerebrospinal fluid (CSF) samples in hydrocephalic diseases such as aqueductal stenosis (AQS, <i>n</i> = 27), normal pressure hy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/4/644 |
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| author | Florian Wilhelmy Matthias Krause Stefan Schob Andreas Merkenschlager Robin Wachowiak Wolfgang Härtig Jürgen Meixensberger Janina Gburek-Augustat Tim Wende |
| author_facet | Florian Wilhelmy Matthias Krause Stefan Schob Andreas Merkenschlager Robin Wachowiak Wolfgang Härtig Jürgen Meixensberger Janina Gburek-Augustat Tim Wende |
| author_sort | Florian Wilhelmy |
| collection | DOAJ |
| description | CSF protein levels are altered in neurological disorders, such as hydrocephalus of different etiologies. In this retrospective observational study, we analyzed cerebrospinal fluid (CSF) samples in hydrocephalic diseases such as aqueductal stenosis (AQS, <i>n</i> = 27), normal pressure hydrocephalus (NPH, <i>n</i> = 24), hydrocephalus communicans (commHC, <i>n</i> = 25) and idiopathic intracranial hypertension (IIH)/pseudotumor cerebri (PC, <i>n</i> = 7) in comparison with neurological patients without hydrocephalic configuration (control, <i>n</i> = 95). CSF was obtained through CSF diversion procedures and lumbar punction and analyzed for protein concentrations according to the institution’s laboratory standards. We found significantly decreased CSF protein levels in patients suffering from AQS (0.13 mg/dL [0.1–0.16 mg/dL] <i>p</i> = 2.28 × 10<sup>−8</sup>) and from PC (0.18 mg/dL [0.12–0.24 mg/dL] <i>p</i> = 0.01) compared with controls (0.34 mg/dL [0.33–0.35 mg/dL]). Protein levels were not altered in patients suffering from commHC and NPH compared with neurologically healthy individuals. We propose that a decrease in CSF protein levels is part of an active counterregulatory mechanism to lower CSF volume and, subsequently, intracranial pressure in specific diseases. Research regarding said mechanism and more specific proteomic research on a cellular level must still be performed to prove this hypothesis. Differences in protein levels between different diseases point to different etiologies and mechanisms in different hydrocephalic pathologies. |
| first_indexed | 2024-03-11T05:08:34Z |
| format | Article |
| id | doaj.art-e99ef49cacc24e2ca574f19525bcf3ea |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T05:08:34Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-e99ef49cacc24e2ca574f19525bcf3ea2023-11-17T18:45:42ZengMDPI AGChildren2227-90672023-03-0110464410.3390/children10040644Cerebrospinal Fluid Protein Concentrations in HydrocephalusFlorian Wilhelmy0Matthias Krause1Stefan Schob2Andreas Merkenschlager3Robin Wachowiak4Wolfgang Härtig5Jürgen Meixensberger6Janina Gburek-Augustat7Tim Wende8Department of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyDivision of Neuroradiology, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyDepartment of Childrens and Adolescence Health, Division of Neuropediatrics, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyDepartment of Pediatric Surgery, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyPaul-Flechsig-Insitute for Brain Research, Liebigstraße 19, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyDepartment of Childrens and Adolescence Health, Division of Neuropediatrics, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, GermanyCSF protein levels are altered in neurological disorders, such as hydrocephalus of different etiologies. In this retrospective observational study, we analyzed cerebrospinal fluid (CSF) samples in hydrocephalic diseases such as aqueductal stenosis (AQS, <i>n</i> = 27), normal pressure hydrocephalus (NPH, <i>n</i> = 24), hydrocephalus communicans (commHC, <i>n</i> = 25) and idiopathic intracranial hypertension (IIH)/pseudotumor cerebri (PC, <i>n</i> = 7) in comparison with neurological patients without hydrocephalic configuration (control, <i>n</i> = 95). CSF was obtained through CSF diversion procedures and lumbar punction and analyzed for protein concentrations according to the institution’s laboratory standards. We found significantly decreased CSF protein levels in patients suffering from AQS (0.13 mg/dL [0.1–0.16 mg/dL] <i>p</i> = 2.28 × 10<sup>−8</sup>) and from PC (0.18 mg/dL [0.12–0.24 mg/dL] <i>p</i> = 0.01) compared with controls (0.34 mg/dL [0.33–0.35 mg/dL]). Protein levels were not altered in patients suffering from commHC and NPH compared with neurologically healthy individuals. We propose that a decrease in CSF protein levels is part of an active counterregulatory mechanism to lower CSF volume and, subsequently, intracranial pressure in specific diseases. Research regarding said mechanism and more specific proteomic research on a cellular level must still be performed to prove this hypothesis. Differences in protein levels between different diseases point to different etiologies and mechanisms in different hydrocephalic pathologies.https://www.mdpi.com/2227-9067/10/4/644cerebrospinal fluidCSF proteinhydrocephalusintracranial pressureaqueductal stenosisnormal pressure hydrocephalus |
| spellingShingle | Florian Wilhelmy Matthias Krause Stefan Schob Andreas Merkenschlager Robin Wachowiak Wolfgang Härtig Jürgen Meixensberger Janina Gburek-Augustat Tim Wende Cerebrospinal Fluid Protein Concentrations in Hydrocephalus Children cerebrospinal fluid CSF protein hydrocephalus intracranial pressure aqueductal stenosis normal pressure hydrocephalus |
| title | Cerebrospinal Fluid Protein Concentrations in Hydrocephalus |
| title_full | Cerebrospinal Fluid Protein Concentrations in Hydrocephalus |
| title_fullStr | Cerebrospinal Fluid Protein Concentrations in Hydrocephalus |
| title_full_unstemmed | Cerebrospinal Fluid Protein Concentrations in Hydrocephalus |
| title_short | Cerebrospinal Fluid Protein Concentrations in Hydrocephalus |
| title_sort | cerebrospinal fluid protein concentrations in hydrocephalus |
| topic | cerebrospinal fluid CSF protein hydrocephalus intracranial pressure aqueductal stenosis normal pressure hydrocephalus |
| url | https://www.mdpi.com/2227-9067/10/4/644 |
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