Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic
As one of the leading causes of death from disease, cancer continues to pose a serious threat to human health globally. Despite the development of novel therapeutic regimens and drugs, the long-term survival of cancer patients is still very low, especially for those whose diagnosis is not caught ear...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/23/3868 |
| _version_ | 1827643324517842944 |
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| author | Yuan Long Bin Xie Hong C. Shen Danyi Wen |
| author_facet | Yuan Long Bin Xie Hong C. Shen Danyi Wen |
| author_sort | Yuan Long |
| collection | DOAJ |
| description | As one of the leading causes of death from disease, cancer continues to pose a serious threat to human health globally. Despite the development of novel therapeutic regimens and drugs, the long-term survival of cancer patients is still very low, especially for those whose diagnosis is not caught early enough. Meanwhile, our understanding of tumorigenesis is still limited. Suitable research models are essential tools for exploring cancer mechanisms and treatments. Herein we review and compare several widely used in vitro and in vivo murine cancer models, including syngeneic tumor models, genetically engineered mouse models (GEMM), cell line-derived xenografts (CDX), patient-derived xenografts (PDX), conditionally reprogrammed (CR) cells, organoids, and MiniPDX. We will summarize the methodology and feasibility of various models in terms of their advantages and limitations in the application prospects for drug discovery and development and precision medicine. |
| first_indexed | 2024-03-09T17:50:51Z |
| format | Article |
| id | doaj.art-e99f4ed845df406d89450ad029fcfb69 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:50:51Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e99f4ed845df406d89450ad029fcfb692023-11-24T10:45:10ZengMDPI AGCells2073-44092022-11-011123386810.3390/cells11233868Translation Potential and Challenges of In Vitro and Murine Models in Cancer ClinicYuan Long0Bin Xie1Hong C. Shen2Danyi Wen3Shanghai LIDE Biotech Co., Ltd., Shanghai 201203, ChinaShanghai LIDE Biotech Co., Ltd., Shanghai 201203, ChinaChina Innovation Center of Roche, Roche R & D Center, Shanghai 201203, ChinaShanghai LIDE Biotech Co., Ltd., Shanghai 201203, ChinaAs one of the leading causes of death from disease, cancer continues to pose a serious threat to human health globally. Despite the development of novel therapeutic regimens and drugs, the long-term survival of cancer patients is still very low, especially for those whose diagnosis is not caught early enough. Meanwhile, our understanding of tumorigenesis is still limited. Suitable research models are essential tools for exploring cancer mechanisms and treatments. Herein we review and compare several widely used in vitro and in vivo murine cancer models, including syngeneic tumor models, genetically engineered mouse models (GEMM), cell line-derived xenografts (CDX), patient-derived xenografts (PDX), conditionally reprogrammed (CR) cells, organoids, and MiniPDX. We will summarize the methodology and feasibility of various models in terms of their advantages and limitations in the application prospects for drug discovery and development and precision medicine.https://www.mdpi.com/2073-4409/11/23/3868cancer modelsPDXCR cellsorganoidMiniPDX |
| spellingShingle | Yuan Long Bin Xie Hong C. Shen Danyi Wen Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic Cells cancer models PDX CR cells organoid MiniPDX |
| title | Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic |
| title_full | Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic |
| title_fullStr | Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic |
| title_full_unstemmed | Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic |
| title_short | Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic |
| title_sort | translation potential and challenges of in vitro and murine models in cancer clinic |
| topic | cancer models PDX CR cells organoid MiniPDX |
| url | https://www.mdpi.com/2073-4409/11/23/3868 |
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