Combinatorial suicide gene strategies for the safety of cell therapies

Combinatorial suicide gene strategies for the safety of cell therapies

Gene-modified cellular therapies carry inherent risks of severe and potentially fatal adverse events, including the expansion of alloreactive cells or malignant transformation due to insertional mutagenesis. Strategies to mitigate uncontrolled proliferation of gene-modified cells include co-transfec...

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Bibliographic Details
Main Authors: Corey Falcon, Lauren Smith, Mustafa Al-Obaidi, Mohammed Abu Zaanona, Katelyn Purvis, Kentaro Minagawa, Mohammad Athar, Donna Salzman, Ravi Bhatia, Frederick Goldman, Antonio Di Stasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
inducible caspase 8
inducible caspase 9
suicide gene
safety switch
RQR8
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.975233/full

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