Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?
Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provid...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5229 |
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| author | Anna Maria Rychter Marzena Skrzypczak-Zielińska Aleksandra Zielińska Piotr Eder Eliana B. Souto Agnieszka Zawada Alicja Ewa Ratajczak Agnieszka Dobrowolska Iwona Krela-Kaźmierczak |
| author_facet | Anna Maria Rychter Marzena Skrzypczak-Zielińska Aleksandra Zielińska Piotr Eder Eliana B. Souto Agnieszka Zawada Alicja Ewa Ratajczak Agnieszka Dobrowolska Iwona Krela-Kaźmierczak |
| author_sort | Anna Maria Rychter |
| collection | DOAJ |
| description | Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group. In our review, we summarized the current knowledge about RBP4 and its association with essential aspects of cardiovascular disease—lipid profile, intima-media thickness, atherosclerotic process, and diet. We also discussed the <i>RBP4</i> gene polymorphisms essential from a cardiovascular perspective. |
| first_indexed | 2024-03-10T18:15:28Z |
| format | Article |
| id | doaj.art-e99fec99a57841e49235aba9e42c346f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:15:28Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e99fec99a57841e49235aba9e42c346f2023-11-20T07:45:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012115522910.3390/ijms21155229Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?Anna Maria Rychter0Marzena Skrzypczak-Zielińska1Aleksandra Zielińska2Piotr Eder3Eliana B. Souto4Agnieszka Zawada5Alicja Ewa Ratajczak6Agnieszka Dobrowolska7Iwona Krela-Kaźmierczak8Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, PolandInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, PolandInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, PolandAlthough many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group. In our review, we summarized the current knowledge about RBP4 and its association with essential aspects of cardiovascular disease—lipid profile, intima-media thickness, atherosclerotic process, and diet. We also discussed the <i>RBP4</i> gene polymorphisms essential from a cardiovascular perspective.https://www.mdpi.com/1422-0067/21/15/5229atherosclerosisRBP4cardiovascular diseaseobesitymetabolic syndromelipoprotein metabolism |
| spellingShingle | Anna Maria Rychter Marzena Skrzypczak-Zielińska Aleksandra Zielińska Piotr Eder Eliana B. Souto Agnieszka Zawada Alicja Ewa Ratajczak Agnieszka Dobrowolska Iwona Krela-Kaźmierczak Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? International Journal of Molecular Sciences atherosclerosis RBP4 cardiovascular disease obesity metabolic syndrome lipoprotein metabolism |
| title | Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? |
| title_full | Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? |
| title_fullStr | Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? |
| title_full_unstemmed | Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? |
| title_short | Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? |
| title_sort | is the retinol binding protein 4 a possible risk factor for cardiovascular diseases in obesity |
| topic | atherosclerosis RBP4 cardiovascular disease obesity metabolic syndrome lipoprotein metabolism |
| url | https://www.mdpi.com/1422-0067/21/15/5229 |
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