Brain metastases in patients with low-grade endometrial carcinoma
Objective: To report characteristics of patients with low-grade endometrioid endometrial carcinoma (EC) who develop brain metastases. Methods: We retrospectively identified all patients treated at our institution for FIGO grades 1/2 EC from 1/2000–12/2016, who developed brain metastases. Electronic...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-11-01
|
| Series: | Gynecologic Oncology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578918300985 |
| _version_ | 1819242108584722432 |
|---|---|
| author | Paulina Cybulska Marina Stasenko Raanan Alter Vicky Makker Karen A. Cadoo Yukio Sonoda Nadeem R. Abu-Rustum Jennifer J. Mueller Mario M. Leitao, Jr. |
| author_facet | Paulina Cybulska Marina Stasenko Raanan Alter Vicky Makker Karen A. Cadoo Yukio Sonoda Nadeem R. Abu-Rustum Jennifer J. Mueller Mario M. Leitao, Jr. |
| author_sort | Paulina Cybulska |
| collection | DOAJ |
| description | Objective: To report characteristics of patients with low-grade endometrioid endometrial carcinoma (EC) who develop brain metastases. Methods: We retrospectively identified all patients treated at our institution for FIGO grades 1/2 EC from 1/2000–12/2016, who developed brain metastases. Electronic medical records were reviewed, data abstracted. Overall survival (OS) was determined from time of brain metastases to death or last follow-up. Appropriate statistical tests were used. Results: Of 3052 patients, 23 (9, grade 1; 14, grade 2) developed brain metastases (incidence = 0.75%). Presentation at initial diagnosis: median age = 61.3 years (range, 41–81); median BMI = 29.8 kg/m2 (range, 20.3–42.6 kg/m2); distribution by stage: I, 15/23 (65%); II, 2/23 (8.7%); III, 3/23 (13.0%); IV, 3 (13.0%). None showed clinical evidence of brain metastases at presentation. Median time to diagnosis of brain metastases = 29.7 months (range, 6–145); median age = 64.6 years (range, 47.5–86.5). Brain metastases were the first, isolated site of recurrence in 2/23 (9%). All presented with neurological symptoms. Six (26%) had solitary brain lesions. Seventeen (74%) received treatment; 6 (28%), supportive care only. Median OS for patients receiving any treatment = 5.8 months (95% CI, 1.6–10.0), versus 2.4 months (95% CI, 1.5–3.3; p = .04) for best supportive care. Conclusion: Brain metastases in low-grade EC is rare, prognosis generally poor. Compared to supportive care only, any treatment results in more favorable outcomes. Keywords: Brain metastases, Endometrial carcinoma, Low-grade endometrial carcinoma |
| first_indexed | 2024-12-23T14:34:34Z |
| format | Article |
| id | doaj.art-e9a0fe5b72dd4783a0910a5ba87e6b45 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-12-23T14:34:34Z |
| publishDate | 2018-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-e9a0fe5b72dd4783a0910a5ba87e6b452022-12-21T17:43:24ZengElsevierGynecologic Oncology Reports2352-57892018-11-01268790Brain metastases in patients with low-grade endometrial carcinomaPaulina Cybulska0Marina Stasenko1Raanan Alter2Vicky Makker3Karen A. Cadoo4Yukio Sonoda5Nadeem R. Abu-Rustum6Jennifer J. Mueller7Mario M. Leitao, Jr.8Memorial Sloan Kettering Cancer Center, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United States; Weill Cornell Medical College, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United States; Weill Cornell Medical College, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United States; Weill Cornell Medical College, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United States; Weill Cornell Medical College, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United States; Weill Cornell Medical College, New York, NY, United StatesMemorial Sloan Kettering Cancer Center, New York, NY, United States; Weill Cornell Medical College, New York, NY, United States; Corresponding author at: Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States.Objective: To report characteristics of patients with low-grade endometrioid endometrial carcinoma (EC) who develop brain metastases. Methods: We retrospectively identified all patients treated at our institution for FIGO grades 1/2 EC from 1/2000–12/2016, who developed brain metastases. Electronic medical records were reviewed, data abstracted. Overall survival (OS) was determined from time of brain metastases to death or last follow-up. Appropriate statistical tests were used. Results: Of 3052 patients, 23 (9, grade 1; 14, grade 2) developed brain metastases (incidence = 0.75%). Presentation at initial diagnosis: median age = 61.3 years (range, 41–81); median BMI = 29.8 kg/m2 (range, 20.3–42.6 kg/m2); distribution by stage: I, 15/23 (65%); II, 2/23 (8.7%); III, 3/23 (13.0%); IV, 3 (13.0%). None showed clinical evidence of brain metastases at presentation. Median time to diagnosis of brain metastases = 29.7 months (range, 6–145); median age = 64.6 years (range, 47.5–86.5). Brain metastases were the first, isolated site of recurrence in 2/23 (9%). All presented with neurological symptoms. Six (26%) had solitary brain lesions. Seventeen (74%) received treatment; 6 (28%), supportive care only. Median OS for patients receiving any treatment = 5.8 months (95% CI, 1.6–10.0), versus 2.4 months (95% CI, 1.5–3.3; p = .04) for best supportive care. Conclusion: Brain metastases in low-grade EC is rare, prognosis generally poor. Compared to supportive care only, any treatment results in more favorable outcomes. Keywords: Brain metastases, Endometrial carcinoma, Low-grade endometrial carcinomahttp://www.sciencedirect.com/science/article/pii/S2352578918300985 |
| spellingShingle | Paulina Cybulska Marina Stasenko Raanan Alter Vicky Makker Karen A. Cadoo Yukio Sonoda Nadeem R. Abu-Rustum Jennifer J. Mueller Mario M. Leitao, Jr. Brain metastases in patients with low-grade endometrial carcinoma Gynecologic Oncology Reports |
| title | Brain metastases in patients with low-grade endometrial carcinoma |
| title_full | Brain metastases in patients with low-grade endometrial carcinoma |
| title_fullStr | Brain metastases in patients with low-grade endometrial carcinoma |
| title_full_unstemmed | Brain metastases in patients with low-grade endometrial carcinoma |
| title_short | Brain metastases in patients with low-grade endometrial carcinoma |
| title_sort | brain metastases in patients with low grade endometrial carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2352578918300985 |
| work_keys_str_mv | AT paulinacybulska brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT marinastasenko brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT raananalter brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT vickymakker brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT karenacadoo brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT yukiosonoda brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT nadeemraburustum brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT jenniferjmueller brainmetastasesinpatientswithlowgradeendometrialcarcinoma AT mariomleitaojr brainmetastasesinpatientswithlowgradeendometrialcarcinoma |