Formulation of oxybutynin chloride microparticle-loaded suppositories: in vitro characterization and in vivo pharmacokinetic study

Formulation of oxybutynin chloride microparticle-loaded suppositories: in vitro characterization and in vivo pharmacokinetic study

Abstract Background Oxybutynin chloride (OXC) is used to treat overactive urinary bladder. OXC is metabolized in the liver to N-desethyloxybutynin, which is mainly responsible for the anticholinergic side effects of OXC. Conventional oxybutynin suppositories formulated earlier have shown most common...

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Bibliographic Details
Main Authors: Anjali Bedse, Hitendra Mahajan, Suchita Dhamane
Format: Article
Language:English
Published: SpringerOpen 2022-03-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Oxybutynin chloride
Microparticles
Sodium alginate
Carbopol 971 P
Poloxamer
Suppository
Online Access:https://doi.org/10.1186/s43094-022-00411-x

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