Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure
An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/1/92/ |
| _version_ | 1818391265786462208 |
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| author | Sihame Benadji Cherifa Rabia Norah Bennamane Saliha Bakhta Rachedine Kaoua Bellara Nedjar-Kolli |
| author_facet | Sihame Benadji Cherifa Rabia Norah Bennamane Saliha Bakhta Rachedine Kaoua Bellara Nedjar-Kolli |
| author_sort | Sihame Benadji |
| collection | DOAJ |
| description | An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine and 1,5-benzodiazepines derivatives. |
| first_indexed | 2024-12-14T05:10:47Z |
| format | Article |
| id | doaj.art-e9a27b3d931d40e3b81b726d28260145 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T05:10:47Z |
| publishDate | 2010-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e9a27b3d931d40e3b81b726d282601452022-12-21T23:15:58ZengMDPI AGMolecules1420-30492010-12-01161929910.3390/molecules16010092Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed ProcedureSihame BenadjiCherifa RabiaNorah BennamaneSaliha BakhtaRachedine KaouaBellara Nedjar-KolliAn efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine and 1,5-benzodiazepines derivatives.http://www.mdpi.com/1420-3049/16/1/92/1,4-diazepine1,5-benzodiazepinedehydroacetic acid1,3-aminomethyl propaneorthophenylene diamineheteropolyacids |
| spellingShingle | Sihame Benadji Cherifa Rabia Norah Bennamane Saliha Bakhta Rachedine Kaoua Bellara Nedjar-Kolli Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure Molecules 1,4-diazepine 1,5-benzodiazepine dehydroacetic acid 1,3-aminomethyl propane orthophenylene diamine heteropolyacids |
| title | Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure |
| title_full | Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure |
| title_fullStr | Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure |
| title_full_unstemmed | Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure |
| title_short | Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure |
| title_sort | synthesis of substituted 1 4 diazepines and 1 5 benzodiazepines using an efficient heteropolyacid catalyzed procedure |
| topic | 1,4-diazepine 1,5-benzodiazepine dehydroacetic acid 1,3-aminomethyl propane orthophenylene diamine heteropolyacids |
| url | http://www.mdpi.com/1420-3049/16/1/92/ |
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