SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition.

Neuronal development orchestrates the formation of an enormous number of synapses that connect the nervous system. In developing presynapses, the core active zone structure has been found to assemble through liquid-liquid phase separation. Here, we find that the phase separation of Caenorhabditis el...

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Bibliographic Details
Main Authors: Nathan A McDonald, Li Tao, Meng-Qiu Dong, Kang Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-12-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002421&type=printable