Molecular cues govern follicular regulatory T cell differentiation
Follicular regulatory T (Tfr) cells are generated with the responses of germinal center (GC). However, the molecular mechanism on the cell generation is still unknown. Our study found that sclerostin domain-containing protein 1, is essential in the process of Tfr cell generation. With the aid of rep...
| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2020-12-01
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| Series: | Di-san junyi daxue xuebao |
| Subjects: | |
| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202010104.htm |
| _version_ | 1819282246230605824 |
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| author | LIU Xindong WU Xin |
| author_facet | LIU Xindong WU Xin |
| author_sort | LIU Xindong |
| collection | DOAJ |
| description | Follicular regulatory T (Tfr) cells are generated with the responses of germinal center (GC). However, the molecular mechanism on the cell generation is still unknown. Our study found that sclerostin domain-containing protein 1, is essential in the process of Tfr cell generation. With the aid of reporter mice, the results of fate tracking and transcriptome assessment indicated that the Tfh cells expressing SOSTDC1 are identified as a unique T cell population, are developed from SOSTDC1- Tfh cells, and have lost their ability to help B cells in the production of antibodies. It is worth noting that lack of SOSTDC1 results in substantially decreased Tfr cell numbers, and enhanced GC responses. In the aspect of mechanism, SOSTDC1 promotes the differentiation of Tfr cells by blocking Wnt-β-catenin signaling axis |
| first_indexed | 2024-12-24T01:12:32Z |
| format | Article |
| id | doaj.art-e9a72925937f41289870b6607cbf3e03 |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-24T01:12:32Z |
| publishDate | 2020-12-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-e9a72925937f41289870b6607cbf3e032022-12-21T17:22:53ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042020-12-0142242355235710.16016/j.1000-5404.202010104Molecular cues govern follicular regulatory T cell differentiationLIU Xindong0WU Xin1Institute of Pathology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Institute of Pathology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Follicular regulatory T (Tfr) cells are generated with the responses of germinal center (GC). However, the molecular mechanism on the cell generation is still unknown. Our study found that sclerostin domain-containing protein 1, is essential in the process of Tfr cell generation. With the aid of reporter mice, the results of fate tracking and transcriptome assessment indicated that the Tfh cells expressing SOSTDC1 are identified as a unique T cell population, are developed from SOSTDC1- Tfh cells, and have lost their ability to help B cells in the production of antibodies. It is worth noting that lack of SOSTDC1 results in substantially decreased Tfr cell numbers, and enhanced GC responses. In the aspect of mechanism, SOSTDC1 promotes the differentiation of Tfr cells by blocking Wnt-β-catenin signaling axishttp://aammt.tmmu.edu.cn/Upload/rhtml/202010104.htmsostdc1follicular helper t cellfollicular regulatory t cellgerminal center response |
| spellingShingle | LIU Xindong WU Xin Molecular cues govern follicular regulatory T cell differentiation Di-san junyi daxue xuebao sostdc1 follicular helper t cell follicular regulatory t cell germinal center response |
| title | Molecular cues govern follicular regulatory T cell differentiation |
| title_full | Molecular cues govern follicular regulatory T cell differentiation |
| title_fullStr | Molecular cues govern follicular regulatory T cell differentiation |
| title_full_unstemmed | Molecular cues govern follicular regulatory T cell differentiation |
| title_short | Molecular cues govern follicular regulatory T cell differentiation |
| title_sort | molecular cues govern follicular regulatory t cell differentiation |
| topic | sostdc1 follicular helper t cell follicular regulatory t cell germinal center response |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202010104.htm |
| work_keys_str_mv | AT liuxindong molecularcuesgovernfollicularregulatorytcelldifferentiation AT wuxin molecularcuesgovernfollicularregulatorytcelldifferentiation |