Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential Oils
<i>Prangos ferulacea</i> (L.) Lindl, which belongs to the Apiaceae family, is a species that mainly grows in the eastern Mediterranean region and in western Asia. It has been largely used in traditional medicine in several countries and it has been shown to possess several interesting bi...
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| author | Natale Badalamenti Viviana Maresca Michela Di Napoli Maurizio Bruno Adriana Basile Anna Zanfardino |
| author_facet | Natale Badalamenti Viviana Maresca Michela Di Napoli Maurizio Bruno Adriana Basile Anna Zanfardino |
| author_sort | Natale Badalamenti |
| collection | DOAJ |
| description | <i>Prangos ferulacea</i> (L.) Lindl, which belongs to the Apiaceae family, is a species that mainly grows in the eastern Mediterranean region and in western Asia. It has been largely used in traditional medicine in several countries and it has been shown to possess several interesting biological properties. With the aim to provide new insights into the phytochemistry and pharmacology of this species, the essential oils of flowers and leaves from a local accession that grows in Sicily (Italy) and has not yet been previously studied were investigated. The chemical composition of both oils, obtained by hydrodistillation from the leaves and flowers, was evaluated by GC-MS. This analysis allowed us to identify a new chemotype, characterized by a large amount of (<i>Z</i>)<i>-β-</i>ocimene. Furthermore, these essential oils have been tested for their possible antimicrobial and antioxidant activity. <i>P. ferulacea</i> essential oils exhibit moderate antimicrobial activity; in particular, the flower essential oil is harmful at low and wide spectrum concentrations. They also exhibit good antioxidant activity in vitro and in particular, it has been shown that the essential oils of the flowers and leaves of <i>P. ferulacea</i> caused a decrease in ROS and an increase in the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione <i>S</i>-transferase (GST) in OZ-stimulated PMNs. Therefore, these essential oils could be considered as promising candidates for pharmaceutical and nutraceutical preparations. |
| first_indexed | 2024-03-09T18:48:27Z |
| format | Article |
| id | doaj.art-e9a78ea5820a40f69ccaf8146534d39b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:27Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e9a78ea5820a40f69ccaf8146534d39b2023-11-24T06:04:03ZengMDPI AGMolecules1420-30492022-11-012721743010.3390/molecules27217430Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential OilsNatale Badalamenti0Viviana Maresca1Michela Di Napoli2Maurizio Bruno3Adriana Basile4Anna Zanfardino5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, ed. 17, 90128 Palermo, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, ed. 17, 90128 Palermo, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy<i>Prangos ferulacea</i> (L.) Lindl, which belongs to the Apiaceae family, is a species that mainly grows in the eastern Mediterranean region and in western Asia. It has been largely used in traditional medicine in several countries and it has been shown to possess several interesting biological properties. With the aim to provide new insights into the phytochemistry and pharmacology of this species, the essential oils of flowers and leaves from a local accession that grows in Sicily (Italy) and has not yet been previously studied were investigated. The chemical composition of both oils, obtained by hydrodistillation from the leaves and flowers, was evaluated by GC-MS. This analysis allowed us to identify a new chemotype, characterized by a large amount of (<i>Z</i>)<i>-β-</i>ocimene. Furthermore, these essential oils have been tested for their possible antimicrobial and antioxidant activity. <i>P. ferulacea</i> essential oils exhibit moderate antimicrobial activity; in particular, the flower essential oil is harmful at low and wide spectrum concentrations. They also exhibit good antioxidant activity in vitro and in particular, it has been shown that the essential oils of the flowers and leaves of <i>P. ferulacea</i> caused a decrease in ROS and an increase in the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione <i>S</i>-transferase (GST) in OZ-stimulated PMNs. Therefore, these essential oils could be considered as promising candidates for pharmaceutical and nutraceutical preparations.https://www.mdpi.com/1420-3049/27/21/7430Apiaceae<i>Prangos ferulacea</i>(<i>Z</i>)-<i>β</i>-ocimeneGC-MSantioxidant activityantimicrobial activity |
| spellingShingle | Natale Badalamenti Viviana Maresca Michela Di Napoli Maurizio Bruno Adriana Basile Anna Zanfardino Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential Oils Molecules Apiaceae <i>Prangos ferulacea</i> (<i>Z</i>)-<i>β</i>-ocimene GC-MS antioxidant activity antimicrobial activity |
| title | Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential Oils |
| title_full | Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential Oils |
| title_fullStr | Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential Oils |
| title_full_unstemmed | Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential Oils |
| title_short | Chemical Composition and Biological Activities of <i>Prangos ferulacea</i> Essential Oils |
| title_sort | chemical composition and biological activities of i prangos ferulacea i essential oils |
| topic | Apiaceae <i>Prangos ferulacea</i> (<i>Z</i>)-<i>β</i>-ocimene GC-MS antioxidant activity antimicrobial activity |
| url | https://www.mdpi.com/1420-3049/27/21/7430 |
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