An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study Protocol
Background: Most of our knowledge about the etiology, course, treatment, and outcome of schizophrenia spectrum and other psychotic disorders stems from Western countries. Data from populations living in other geographical areas and low- and middle-income countries, with different genomes (ethnicity)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627960/full |
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| author | Sara Farhang Sara Farhang Mehrdad Ghaemmaghami Ali Reza Shafiee-Kandjani Ali Reza Shafiee-Kandjani Seyed Gholamreza Noorazar Wim Veling Ayyoub Malek Mohammad Hossein Somi Richard Bruggeman Behrooz Z. Alizadeh Behrooz Z. Alizadeh |
| author_facet | Sara Farhang Sara Farhang Mehrdad Ghaemmaghami Ali Reza Shafiee-Kandjani Ali Reza Shafiee-Kandjani Seyed Gholamreza Noorazar Wim Veling Ayyoub Malek Mohammad Hossein Somi Richard Bruggeman Behrooz Z. Alizadeh Behrooz Z. Alizadeh |
| author_sort | Sara Farhang |
| collection | DOAJ |
| description | Background: Most of our knowledge about the etiology, course, treatment, and outcome of schizophrenia spectrum and other psychotic disorders stems from Western countries. Data from populations living in other geographical areas and low- and middle-income countries, with different genomes (ethnicity) and exposomes (e.g., culture and social support, drugs of abuse, religion), will add to our knowledge of this complex disorder.Methods: The Azeri Acute phase/Recent onset psychosis Survey (ARAS) has been initiated to study the course of the disorder in patients with recent-onset psychosis using validated diagnostic tools and a comprehensive outcome monitoring system, aiming to reveal indicators for understanding the risk and resilience factors and for choosing the best-personalized treatment strategy. All participants will be evaluated for clinical signs and symptoms as well as risk and resilience factors and will be followed up for 1, 3, and 5 years for outcomes in several domains. A hierarchical cluster method will be applied to identify the number of clusters for each outcome. Defined models will be applied to assess the predictive value of cognition on symptomatic and functional outcomes at follow-up.Discussion: The ARAS cohort will yield significant academic- (research and education) and care-related achievements. ARAS data and experience will have value both in being a useful model for other parts of this region and in an expansion of the currently available knowledge. |
| first_indexed | 2024-12-14T22:19:16Z |
| format | Article |
| id | doaj.art-e9a79fb235244321be49e71c4b90c9b1 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-14T22:19:16Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e9a79fb235244321be49e71c4b90c9b12022-12-21T22:45:33ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-02-011210.3389/fpsyt.2021.627960627960An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study ProtocolSara Farhang0Sara Farhang1Mehrdad Ghaemmaghami2Ali Reza Shafiee-Kandjani3Ali Reza Shafiee-Kandjani4Seyed Gholamreza Noorazar5Wim Veling6Ayyoub Malek7Mohammad Hossein Somi8Richard Bruggeman9Behrooz Z. Alizadeh10Behrooz Z. Alizadeh11University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, University of Groningen, Groningen, NetherlandsResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, IranResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, IranResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, IranFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, IranLiver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranUniversity Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, University of Groningen, Groningen, NetherlandsUniversity Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, University of Groningen, Groningen, NetherlandsDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsBackground: Most of our knowledge about the etiology, course, treatment, and outcome of schizophrenia spectrum and other psychotic disorders stems from Western countries. Data from populations living in other geographical areas and low- and middle-income countries, with different genomes (ethnicity) and exposomes (e.g., culture and social support, drugs of abuse, religion), will add to our knowledge of this complex disorder.Methods: The Azeri Acute phase/Recent onset psychosis Survey (ARAS) has been initiated to study the course of the disorder in patients with recent-onset psychosis using validated diagnostic tools and a comprehensive outcome monitoring system, aiming to reveal indicators for understanding the risk and resilience factors and for choosing the best-personalized treatment strategy. All participants will be evaluated for clinical signs and symptoms as well as risk and resilience factors and will be followed up for 1, 3, and 5 years for outcomes in several domains. A hierarchical cluster method will be applied to identify the number of clusters for each outcome. Defined models will be applied to assess the predictive value of cognition on symptomatic and functional outcomes at follow-up.Discussion: The ARAS cohort will yield significant academic- (research and education) and care-related achievements. ARAS data and experience will have value both in being a useful model for other parts of this region and in an expansion of the currently available knowledge.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627960/fullschizophreniafirst episode psychosis (FEP)social contextcognitiongene-environement interactions |
| spellingShingle | Sara Farhang Sara Farhang Mehrdad Ghaemmaghami Ali Reza Shafiee-Kandjani Ali Reza Shafiee-Kandjani Seyed Gholamreza Noorazar Wim Veling Ayyoub Malek Mohammad Hossein Somi Richard Bruggeman Behrooz Z. Alizadeh Behrooz Z. Alizadeh An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study Protocol Frontiers in Psychiatry schizophrenia first episode psychosis (FEP) social context cognition gene-environement interactions |
| title | An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study Protocol |
| title_full | An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study Protocol |
| title_fullStr | An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study Protocol |
| title_full_unstemmed | An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study Protocol |
| title_short | An Observational Cohort of First Episode Psychosis in Iran: The Azeri Recent Onset Acute Phase Psychosis Survey (ARAS Cohort) Study Protocol |
| title_sort | observational cohort of first episode psychosis in iran the azeri recent onset acute phase psychosis survey aras cohort study protocol |
| topic | schizophrenia first episode psychosis (FEP) social context cognition gene-environement interactions |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627960/full |
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