Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)]

Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)]

Hexavalent Chromium [Cr (VI)] is an established toxicant, carcinogen, and a significant source of public health concern. The multicopy ribosomal DNA (rDNA) array is mechanistically linked to aging and cancer, is the most evolutionarily conserved segment of the human genome, and gives origin to nucle...

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Detalles Bibliográficos
Main Authors: Jianlin Lou, Shoukai Yu, Lingfang Feng, Xinnian Guo, Meng Wang, Alan T. Branco, Tao Li, Bernardo Lemos
Formato: Artigo
Idioma:English
Publicado: Elsevier 2021-08-01
Series:Environment International
Subjects:
Chromium
Ribosome
rDNA
Nucleolus
Copy number
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S0160412021001501

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