Spectrum of human Pasteurella species infections in tropical Australia.
<h4>Background</h4>Acquired zoonotic infections with Pasteurella bacterial species have a wide clinical spectrum of disease from invasive infections to localised bite-wound infections.<h4>Methods</h4>This study reviewed the spectrum of the demographic, clinical, temporal, and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0281164 |
| _version_ | 1797862146429681664 |
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| author | Michelle Mahony Dimitrios Menouhos Jann Hennessy Robert W Baird |
| author_facet | Michelle Mahony Dimitrios Menouhos Jann Hennessy Robert W Baird |
| author_sort | Michelle Mahony |
| collection | DOAJ |
| description | <h4>Background</h4>Acquired zoonotic infections with Pasteurella bacterial species have a wide clinical spectrum of disease from invasive infections to localised bite-wound infections.<h4>Methods</h4>This study reviewed the spectrum of the demographic, clinical, temporal, and microbiological trends of laboratory confirmed Pasteurella species infections presenting to a single-centre tropical tertiary hospital over a twenty-year period.<h4>Results</h4>195 episodes from 190 patients were included. 51.3% patients were female, and 20.5% Aboriginal or Torres Strait Islander peoples. Crude incidence of Pasteurella spp. infections increased from 1.5 per 100,000 population in 2000, to 11.4 per 100,000 population in 2021. There were 22 (11.3%) bloodstream infections, 22 (11.3%) invasive, 34 (17.4%) deep local, 98 (50.2%) superficial infections, and 19 (9.7%) other or unknown. Adults over 65 years of age accounted for the majority of bacteraemias (63.7%). More severe infections, including bacteraemia, invasive and deep local infections, were more common in lower limb infections and in those with underlying comorbidities. Animal contact with cats was more common in bloodstream infections (36.4%), but dog bites more common in invasive, deep local and superficial infections. 30-day all-cause mortality was low at 1.0%. Pasteurella multocida was most commonly identified (61.1%), but P. canis, P. dagmatis, and other Pasteurella infections were also noted. 67.7% of specimens were polymicrobial, with other significant organisms being Staphylococcus aureus, Streptococcus pyogenes, Group G Streptococcus and Pseudomonas aeruginosa.<h4>Conclusion</h4>Pasteurella species remain clinically important pathogens, with the ability to cause severe and invasive infections with associated morbidity. Presentations to hospital are becoming more common, and the polymicrobial nature of bites wounds has implications for empiric antibiotic guidelines. |
| first_indexed | 2024-04-09T22:14:34Z |
| format | Article |
| id | doaj.art-e9ab66d22c794635b89fbd93facdc23b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T22:14:34Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e9ab66d22c794635b89fbd93facdc23b2023-03-23T05:32:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181e028116410.1371/journal.pone.0281164Spectrum of human Pasteurella species infections in tropical Australia.Michelle MahonyDimitrios MenouhosJann HennessyRobert W Baird<h4>Background</h4>Acquired zoonotic infections with Pasteurella bacterial species have a wide clinical spectrum of disease from invasive infections to localised bite-wound infections.<h4>Methods</h4>This study reviewed the spectrum of the demographic, clinical, temporal, and microbiological trends of laboratory confirmed Pasteurella species infections presenting to a single-centre tropical tertiary hospital over a twenty-year period.<h4>Results</h4>195 episodes from 190 patients were included. 51.3% patients were female, and 20.5% Aboriginal or Torres Strait Islander peoples. Crude incidence of Pasteurella spp. infections increased from 1.5 per 100,000 population in 2000, to 11.4 per 100,000 population in 2021. There were 22 (11.3%) bloodstream infections, 22 (11.3%) invasive, 34 (17.4%) deep local, 98 (50.2%) superficial infections, and 19 (9.7%) other or unknown. Adults over 65 years of age accounted for the majority of bacteraemias (63.7%). More severe infections, including bacteraemia, invasive and deep local infections, were more common in lower limb infections and in those with underlying comorbidities. Animal contact with cats was more common in bloodstream infections (36.4%), but dog bites more common in invasive, deep local and superficial infections. 30-day all-cause mortality was low at 1.0%. Pasteurella multocida was most commonly identified (61.1%), but P. canis, P. dagmatis, and other Pasteurella infections were also noted. 67.7% of specimens were polymicrobial, with other significant organisms being Staphylococcus aureus, Streptococcus pyogenes, Group G Streptococcus and Pseudomonas aeruginosa.<h4>Conclusion</h4>Pasteurella species remain clinically important pathogens, with the ability to cause severe and invasive infections with associated morbidity. Presentations to hospital are becoming more common, and the polymicrobial nature of bites wounds has implications for empiric antibiotic guidelines.https://doi.org/10.1371/journal.pone.0281164 |
| spellingShingle | Michelle Mahony Dimitrios Menouhos Jann Hennessy Robert W Baird Spectrum of human Pasteurella species infections in tropical Australia. PLoS ONE |
| title | Spectrum of human Pasteurella species infections in tropical Australia. |
| title_full | Spectrum of human Pasteurella species infections in tropical Australia. |
| title_fullStr | Spectrum of human Pasteurella species infections in tropical Australia. |
| title_full_unstemmed | Spectrum of human Pasteurella species infections in tropical Australia. |
| title_short | Spectrum of human Pasteurella species infections in tropical Australia. |
| title_sort | spectrum of human pasteurella species infections in tropical australia |
| url | https://doi.org/10.1371/journal.pone.0281164 |
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