Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss
Objective: To determine whether trophectoderm (TE) grade or inner cell mass (ICM) grade have predictive value after euploid frozen embryo transfer (euFET) among recurrent pregnancy loss (RPL) patients. Design: Retrospective cohort study. Setting: Single fertility center. Patient(s): Women with ≥2 pr...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-09-01
|
| Series: | F&S Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334120300404 |
| _version_ | 1818556107360043008 |
|---|---|
| author | Gayathree Murugappan, M.D. Julia G. Kim, M.D. Jonathan D. Kort, M.D. Brent M. Hanson, M.D. Shelby A. Neal, M.D. Ashley W. Tiegs, M.D. Emily K. Osman, M.D. Richard T. Scott, M.D. Ruth B. Lathi, M.D. |
| author_facet | Gayathree Murugappan, M.D. Julia G. Kim, M.D. Jonathan D. Kort, M.D. Brent M. Hanson, M.D. Shelby A. Neal, M.D. Ashley W. Tiegs, M.D. Emily K. Osman, M.D. Richard T. Scott, M.D. Ruth B. Lathi, M.D. |
| author_sort | Gayathree Murugappan, M.D. |
| collection | DOAJ |
| description | Objective: To determine whether trophectoderm (TE) grade or inner cell mass (ICM) grade have predictive value after euploid frozen embryo transfer (euFET) among recurrent pregnancy loss (RPL) patients. Design: Retrospective cohort study. Setting: Single fertility center. Patient(s): Women with ≥2 prior pregnancy losses with ≥1 euploid embryo for transfer undergoing preimplantation genetic testing for aneuploidy. Intervention(s): Intracytoplasmic sperm injection, TE biopsy, blastocyst grading and vitrification, and single euFET, with first transfer outcome recorded. Main Outcome Measure(s): Live birth and clinical miscarriage rates. Result(s): The study included 660 euFET cycles. In a binomial logistic regression analysis accounting for age, body mass index, antimüllerian hormone level, and day of blastocyst biopsy, or ICM grade C was not significantly associated with odds of live birth, miscarriage, or biochemical pregnancy loss. TE grade C was significantly associated with odds of live birth and was not associated with odds of miscarriage or biochemical pregnancy loss. Blastocyst grade CC had significantly lower live birth rate compared with all other blastocyst grades. Conclusion(s): Embryo grade CC and TE grade C are associated with decreased odds of live birth after euFET in RPL patients. Embryo grade is not associated with odds of clinical miscarriage in this cohort of RPL patients, suggesting that additional embryonic or uterine factors may influence the risk of pregnancy loss. |
| first_indexed | 2024-12-13T23:43:12Z |
| format | Article |
| id | doaj.art-e9abfb22429e4bdab57be5b2334cb28a |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-12-13T23:43:12Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-e9abfb22429e4bdab57be5b2334cb28a2022-12-21T23:27:07ZengElsevierF&S Reports2666-33412020-09-0112113118Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy lossGayathree Murugappan, M.D.0Julia G. Kim, M.D.1Jonathan D. Kort, M.D.2Brent M. Hanson, M.D.3Shelby A. Neal, M.D.4Ashley W. Tiegs, M.D.5Emily K. Osman, M.D.6Richard T. Scott, M.D.7Ruth B. Lathi, M.D.8Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University, Sunnyvale, California; Reprint requests: Gayathree Murugappan, M.D., Stanford Department of Reproductive Endocrinology and Infertility, 1195 W. Fremont Avenue, Sunnyvale, California 94087.IVI/Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PennsylvaniaIVI/Reproductive Medicine Associates of Northern California, Palo Alto, CaliforniaIVI/Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PennsylvaniaIVI/Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PennsylvaniaIVI/Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PennsylvaniaIVI/Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PennsylvaniaIVI/Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PennsylvaniaDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University, Sunnyvale, CaliforniaObjective: To determine whether trophectoderm (TE) grade or inner cell mass (ICM) grade have predictive value after euploid frozen embryo transfer (euFET) among recurrent pregnancy loss (RPL) patients. Design: Retrospective cohort study. Setting: Single fertility center. Patient(s): Women with ≥2 prior pregnancy losses with ≥1 euploid embryo for transfer undergoing preimplantation genetic testing for aneuploidy. Intervention(s): Intracytoplasmic sperm injection, TE biopsy, blastocyst grading and vitrification, and single euFET, with first transfer outcome recorded. Main Outcome Measure(s): Live birth and clinical miscarriage rates. Result(s): The study included 660 euFET cycles. In a binomial logistic regression analysis accounting for age, body mass index, antimüllerian hormone level, and day of blastocyst biopsy, or ICM grade C was not significantly associated with odds of live birth, miscarriage, or biochemical pregnancy loss. TE grade C was significantly associated with odds of live birth and was not associated with odds of miscarriage or biochemical pregnancy loss. Blastocyst grade CC had significantly lower live birth rate compared with all other blastocyst grades. Conclusion(s): Embryo grade CC and TE grade C are associated with decreased odds of live birth after euFET in RPL patients. Embryo grade is not associated with odds of clinical miscarriage in this cohort of RPL patients, suggesting that additional embryonic or uterine factors may influence the risk of pregnancy loss.http://www.sciencedirect.com/science/article/pii/S2666334120300404Embryo gradeeuploid transfermiscarriagePGT-Arecurrent pregnancy loss |
| spellingShingle | Gayathree Murugappan, M.D. Julia G. Kim, M.D. Jonathan D. Kort, M.D. Brent M. Hanson, M.D. Shelby A. Neal, M.D. Ashley W. Tiegs, M.D. Emily K. Osman, M.D. Richard T. Scott, M.D. Ruth B. Lathi, M.D. Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss F&S Reports Embryo grade euploid transfer miscarriage PGT-A recurrent pregnancy loss |
| title | Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss |
| title_full | Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss |
| title_fullStr | Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss |
| title_full_unstemmed | Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss |
| title_short | Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss |
| title_sort | prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss |
| topic | Embryo grade euploid transfer miscarriage PGT-A recurrent pregnancy loss |
| url | http://www.sciencedirect.com/science/article/pii/S2666334120300404 |
| work_keys_str_mv | AT gayathreemurugappanmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT juliagkimmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT jonathandkortmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT brentmhansonmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT shelbyanealmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT ashleywtiegsmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT emilykosmanmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT richardtscottmd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss AT ruthblathimd prognosticvalueofblastocystgradeafterfrozeneuploidembryotransferinpatientswithrecurrentpregnancyloss |