Development of an Assay for Soy Isoflavones in Women’s Hair
Soy isoflavones, at adequate dosages, have estrogenic and anti-thyroidal effects in animals and humans, which can either be beneficial or adverse, depending on the consumer’s physiological status. Hence, this study presents an assay of soy isoflavones in hair, aiming to give new information about a...
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| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3619 |
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| author | Souad Bensaada Isabelle Raymond Malena Breton Isabelle Pellegrin Jean-François Viallard Catherine Bennetau-Pelissero |
| author_facet | Souad Bensaada Isabelle Raymond Malena Breton Isabelle Pellegrin Jean-François Viallard Catherine Bennetau-Pelissero |
| author_sort | Souad Bensaada |
| collection | DOAJ |
| description | Soy isoflavones, at adequate dosages, have estrogenic and anti-thyroidal effects in animals and humans, which can either be beneficial or adverse, depending on the consumer’s physiological status. Hence, this study presents an assay of soy isoflavones in hair, aiming to give new information about a person’s exposure to isoflavones, when health issues related to estrogenic or thyroidal effects are observed. Aqueous or organic extraction procedures following acidic, basic, or enzymatic digestions were tested on 60 hair samples (from volunteers) from a hairdresser, and a clinical trial 2017T2-29. The acidic digestion method was the most efficient regarding isoflavones. A specific inquiry was developed to assess the dietary habits of French consumers based on the analysis of 12,707 food labels from France. It was used to check for the reliability of the new assay method. A score for the consumer exposures to isoflavones was built considering, among other parameters, soy-based diets and foodstuff containing soy as an ingredient, i.e., “hidden-soy”. The correlation between this score and isoflavone measurements in hair reached 0.947; <i>p</i> < 0.001. Therefore, providing that relevant data are considered to assess isoflavone exposure, hair that smoothens daily isoflavone intake variations, is a relevant tissue to assess human isoflavone exposure for subsequent health analyses. |
| first_indexed | 2024-03-10T01:25:20Z |
| format | Article |
| id | doaj.art-e9aece7a89db4123931269b565d1992b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:25:20Z |
| publishDate | 2022-09-01 |
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| series | Nutrients |
| spelling | doaj.art-e9aece7a89db4123931269b565d1992b2023-11-23T13:53:32ZengMDPI AGNutrients2072-66432022-09-011417361910.3390/nu14173619Development of an Assay for Soy Isoflavones in Women’s HairSouad Bensaada0Isabelle Raymond1Malena Breton2Isabelle Pellegrin3Jean-François Viallard4Catherine Bennetau-Pelissero5Carreire Campus, Sciences and Technology Department, Pharmacy Faculty, University of Bordeaux, 33076 Bordeaux, FranceCarreire Campus, Sciences and Technology Department, Pharmacy Faculty, University of Bordeaux, 33076 Bordeaux, FranceCarreire Campus, Sciences and Technology Department, Pharmacy Faculty, University of Bordeaux, 33076 Bordeaux, FranceCarreire Campus, Sciences and Technology Department, Pharmacy Faculty, University of Bordeaux, 33076 Bordeaux, FranceCarreire Campus, Sciences and Technology Department, Pharmacy Faculty, University of Bordeaux, 33076 Bordeaux, FranceCarreire Campus, Sciences and Technology Department, Pharmacy Faculty, University of Bordeaux, 33076 Bordeaux, FranceSoy isoflavones, at adequate dosages, have estrogenic and anti-thyroidal effects in animals and humans, which can either be beneficial or adverse, depending on the consumer’s physiological status. Hence, this study presents an assay of soy isoflavones in hair, aiming to give new information about a person’s exposure to isoflavones, when health issues related to estrogenic or thyroidal effects are observed. Aqueous or organic extraction procedures following acidic, basic, or enzymatic digestions were tested on 60 hair samples (from volunteers) from a hairdresser, and a clinical trial 2017T2-29. The acidic digestion method was the most efficient regarding isoflavones. A specific inquiry was developed to assess the dietary habits of French consumers based on the analysis of 12,707 food labels from France. It was used to check for the reliability of the new assay method. A score for the consumer exposures to isoflavones was built considering, among other parameters, soy-based diets and foodstuff containing soy as an ingredient, i.e., “hidden-soy”. The correlation between this score and isoflavone measurements in hair reached 0.947; <i>p</i> < 0.001. Therefore, providing that relevant data are considered to assess isoflavone exposure, hair that smoothens daily isoflavone intake variations, is a relevant tissue to assess human isoflavone exposure for subsequent health analyses.https://www.mdpi.com/2072-6643/14/17/3619soy isoflavonesconsumer exposurehair samplesdietary inquirydigestion method |
| spellingShingle | Souad Bensaada Isabelle Raymond Malena Breton Isabelle Pellegrin Jean-François Viallard Catherine Bennetau-Pelissero Development of an Assay for Soy Isoflavones in Women’s Hair Nutrients soy isoflavones consumer exposure hair samples dietary inquiry digestion method |
| title | Development of an Assay for Soy Isoflavones in Women’s Hair |
| title_full | Development of an Assay for Soy Isoflavones in Women’s Hair |
| title_fullStr | Development of an Assay for Soy Isoflavones in Women’s Hair |
| title_full_unstemmed | Development of an Assay for Soy Isoflavones in Women’s Hair |
| title_short | Development of an Assay for Soy Isoflavones in Women’s Hair |
| title_sort | development of an assay for soy isoflavones in women s hair |
| topic | soy isoflavones consumer exposure hair samples dietary inquiry digestion method |
| url | https://www.mdpi.com/2072-6643/14/17/3619 |
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