Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnography
Hallucination is a common non-motor symptom in patients with Parkinson's disease (PD). Additionally, sleep disorders are associated with an increased risk of hallucinations in PD patients. This study aimed to examine the association between hallucination and objective sleep parameters in PD pat...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.929569/full |
| _version_ | 1811326913565687808 |
|---|---|
| author | Ruxin Gu Jun Zhu Min Zhong Yinyin Jiang Sha Zhu Yaxi Wang Xu Jiang Bo Shen Jun Yan Li Zhang Li Zhang Yang Pan |
| author_facet | Ruxin Gu Jun Zhu Min Zhong Yinyin Jiang Sha Zhu Yaxi Wang Xu Jiang Bo Shen Jun Yan Li Zhang Li Zhang Yang Pan |
| author_sort | Ruxin Gu |
| collection | DOAJ |
| description | Hallucination is a common non-motor symptom in patients with Parkinson's disease (PD). Additionally, sleep disorders are associated with an increased risk of hallucinations in PD patients. This study aimed to examine the association between hallucination and objective sleep parameters in PD patients. We retrospectively recruited 278 PD patients who underwent polysomnography and clinical assessments and classified them into non-hallucination and hallucination groups. Hallucinations were observed in 77 older PD patients who had more severe motor symptoms and higher scores on the Non-Motor Symptoms Questionnaire (NMSQ), Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) but lower scores on the Montreal Cognitive Assessment (MOCA) and PD Sleep Scale (PDSS) than PD patients without hallucinations. Analysis of the polysomnographic variables in patients with hallucinations showed that they exhibited a decrease in total sleep time, sleep efficiency (SE), rapid eye movement (REM) sleep time and slow wave sleep (SWS, N3) time and percentage but a significant increase in wake time after sleep onset (WASO), periodic limb movement index (PLMI) scores, and stage 2 NREM (N2)percentage. Logistic regression analysis revealed that higher NMSQ scores, lower MOCA scores, lower SE, and a lower percentage of N3 sleep were associated with hallucinations in PD patients. Our results suggested that PD patients with hallucinations had worse sleep quality and differences in sleep architecture (measured by polysomnography). |
| first_indexed | 2024-04-13T14:57:36Z |
| format | Article |
| id | doaj.art-e9b01900bc6d49dabc4bc9ea9d426ce4 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T14:57:36Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e9b01900bc6d49dabc4bc9ea9d426ce42022-12-22T02:42:24ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.929569929569Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnographyRuxin Gu0Jun Zhu1Min Zhong2Yinyin Jiang3Sha Zhu4Yaxi Wang5Xu Jiang6Bo Shen7Jun Yan8Li Zhang9Li Zhang10Yang Pan11Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaInstitute of Neuropsychiatric Diseases, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaHallucination is a common non-motor symptom in patients with Parkinson's disease (PD). Additionally, sleep disorders are associated with an increased risk of hallucinations in PD patients. This study aimed to examine the association between hallucination and objective sleep parameters in PD patients. We retrospectively recruited 278 PD patients who underwent polysomnography and clinical assessments and classified them into non-hallucination and hallucination groups. Hallucinations were observed in 77 older PD patients who had more severe motor symptoms and higher scores on the Non-Motor Symptoms Questionnaire (NMSQ), Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) but lower scores on the Montreal Cognitive Assessment (MOCA) and PD Sleep Scale (PDSS) than PD patients without hallucinations. Analysis of the polysomnographic variables in patients with hallucinations showed that they exhibited a decrease in total sleep time, sleep efficiency (SE), rapid eye movement (REM) sleep time and slow wave sleep (SWS, N3) time and percentage but a significant increase in wake time after sleep onset (WASO), periodic limb movement index (PLMI) scores, and stage 2 NREM (N2)percentage. Logistic regression analysis revealed that higher NMSQ scores, lower MOCA scores, lower SE, and a lower percentage of N3 sleep were associated with hallucinations in PD patients. Our results suggested that PD patients with hallucinations had worse sleep quality and differences in sleep architecture (measured by polysomnography).https://www.frontiersin.org/articles/10.3389/fneur.2022.929569/fullParkinson's diseasehallucinationsleep disordersslow wave sleepsleep quality |
| spellingShingle | Ruxin Gu Jun Zhu Min Zhong Yinyin Jiang Sha Zhu Yaxi Wang Xu Jiang Bo Shen Jun Yan Li Zhang Li Zhang Yang Pan Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnography Frontiers in Neurology Parkinson's disease hallucination sleep disorders slow wave sleep sleep quality |
| title | Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnography |
| title_full | Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnography |
| title_fullStr | Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnography |
| title_full_unstemmed | Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnography |
| title_short | Characteristics of sleep structure in Parkinson's disease patients with hallucinations based on polysomnography |
| title_sort | characteristics of sleep structure in parkinson s disease patients with hallucinations based on polysomnography |
| topic | Parkinson's disease hallucination sleep disorders slow wave sleep sleep quality |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.929569/full |
| work_keys_str_mv | AT ruxingu characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT junzhu characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT minzhong characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT yinyinjiang characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT shazhu characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT yaxiwang characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT xujiang characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT boshen characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT junyan characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT lizhang characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT lizhang characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography AT yangpan characteristicsofsleepstructureinparkinsonsdiseasepatientswithhallucinationsbasedonpolysomnography |