Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology
The changes in subfoveal choroidal thickness after orthokeratology are crucial in myopia retardation; this study aimed to identify the risk factors that could be incorporated into a predictive model for subfoveal choroidal thickness (SFChT) that would provide further personalized and clinically spec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/8/1316 |
| _version_ | 1797432061205676032 |
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| author | Xiaohang Chen Qiushi Li Longqian Liu |
| author_facet | Xiaohang Chen Qiushi Li Longqian Liu |
| author_sort | Xiaohang Chen |
| collection | DOAJ |
| description | The changes in subfoveal choroidal thickness after orthokeratology are crucial in myopia retardation; this study aimed to identify the risk factors that could be incorporated into a predictive model for subfoveal choroidal thickness (SFChT) that would provide further personalized and clinically specific information for myopia control. A one-year prospective study was conducted in the West China Hospital, Sichuan University. Basic information (age, gender, and height) was collected from all subjects. Initial spherical equivalent, axial length, intraocular pressure, central corneal thickness, and subfoveal choroidal thickness were measured, and the ocular environmental factors were also collected. All the measured parameters were recorded in the follow-up period for one year. After the analysis of univariate analysis, statistically significant factors were substituted into the multivariate three-level model. Thirty-three adolescents aged 8–14 years old were enrolled in this study; the results show that the subfoveal choroidal thickness in both eyes changed significantly after 12 months of lens wearing (<i>p</i><sub>R</sub> < 0.0001, <i>p</i><sub>L</sub> < 0.0001). The axial length was negatively correlated with the change in the SFChT after 12 months of lens wearing (r = −0.511, <i>p</i> = 0.002). After multilevel model analysis, the statistically significant factor was shown to have an important influence on the changes in the subfoveal choroidal thickness, which was the average near-work time. This suggested that the SFChT personal predictions can be made regarding changes in myopic adolescents after orthokeratology using the factor of daily average near-work time. Clinical practitioners will benefit from the results by obtaining a better understanding of the effects of orthokeratology on choroid and myopia progression. |
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| format | Article |
| id | doaj.art-e9b1d412b1ed410081425b6b020ddb31 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T09:54:50Z |
| publishDate | 2022-08-01 |
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| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-e9b1d412b1ed410081425b6b020ddb312023-12-01T23:52:58ZengMDPI AGJournal of Personalized Medicine2075-44262022-08-01128131610.3390/jpm12081316Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight OrthokeratologyXiaohang Chen0Qiushi Li1Longqian Liu2Department of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Outpatient, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu 610041, ChinaThe changes in subfoveal choroidal thickness after orthokeratology are crucial in myopia retardation; this study aimed to identify the risk factors that could be incorporated into a predictive model for subfoveal choroidal thickness (SFChT) that would provide further personalized and clinically specific information for myopia control. A one-year prospective study was conducted in the West China Hospital, Sichuan University. Basic information (age, gender, and height) was collected from all subjects. Initial spherical equivalent, axial length, intraocular pressure, central corneal thickness, and subfoveal choroidal thickness were measured, and the ocular environmental factors were also collected. All the measured parameters were recorded in the follow-up period for one year. After the analysis of univariate analysis, statistically significant factors were substituted into the multivariate three-level model. Thirty-three adolescents aged 8–14 years old were enrolled in this study; the results show that the subfoveal choroidal thickness in both eyes changed significantly after 12 months of lens wearing (<i>p</i><sub>R</sub> < 0.0001, <i>p</i><sub>L</sub> < 0.0001). The axial length was negatively correlated with the change in the SFChT after 12 months of lens wearing (r = −0.511, <i>p</i> = 0.002). After multilevel model analysis, the statistically significant factor was shown to have an important influence on the changes in the subfoveal choroidal thickness, which was the average near-work time. This suggested that the SFChT personal predictions can be made regarding changes in myopic adolescents after orthokeratology using the factor of daily average near-work time. Clinical practitioners will benefit from the results by obtaining a better understanding of the effects of orthokeratology on choroid and myopia progression.https://www.mdpi.com/2075-4426/12/8/1316choroidal thicknessorthokeratologymyopiamultilevel modeladolescentssubfoveal choroidal thickness |
| spellingShingle | Xiaohang Chen Qiushi Li Longqian Liu Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology Journal of Personalized Medicine choroidal thickness orthokeratology myopia multilevel model adolescents subfoveal choroidal thickness |
| title | Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology |
| title_full | Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology |
| title_fullStr | Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology |
| title_full_unstemmed | Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology |
| title_short | Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology |
| title_sort | personalized predictive modeling of subfoveal choroidal thickness changes for myopic adolescents after overnight orthokeratology |
| topic | choroidal thickness orthokeratology myopia multilevel model adolescents subfoveal choroidal thickness |
| url | https://www.mdpi.com/2075-4426/12/8/1316 |
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