Serum Procalcitonin as a Diagnostic Marker for Systemic Inflammatory Response Syndrome in Intensive Care Unit Patients
Introduction: Early assessment of Systemic Inflammatory Response Syndrome (SIRS) through various biomarkers like Procalcitonin (PCT), C-reactive Protein (CRP), Interleukin-1 (IL-1) etc., is crucial to manage the outcome of patients. Levels of PCT concerning its likelihood to distinguish patients...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2020-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/14332/46871_CE[AG]_F(SL)_PF1(AG_SL)_PN(SL).pdf |
| Summary: | Introduction: Early assessment of Systemic Inflammatory
Response Syndrome (SIRS) through various biomarkers like
Procalcitonin (PCT), C-reactive Protein (CRP), Interleukin-1 (IL-1)
etc., is crucial to manage the outcome of patients. Levels of PCT
concerning its likelihood to distinguish patients with SIRS and
non-SIRS and the possibility to predict mortality in patients with
sepsis has been variable.
Aim: To investigate the role of PCT in early diagnosis of sepsis
in patients admitted to Intensive Care Unit (ICU).
Materials and Methods: In this prospective observational
study, 136 patients hospitalised in ICU at Vydehi Institute of
Medical Sciences and Research Centre, Bangalore, Karnataka,
India, between July 2019 to June 2020 were evaluated and
PCT was analysed using Finecare™ PCT rapid test. Receiver
Operating Characteristic (ROC) curve analysis and multiple
logistic regression was carried out to detect the association of
predictive PCT value with its outcomes.
Results: PCT showed the best predictive value in the diagnosis
of SIRS at 1.68 ng/mL (Area Under Curve (AUC)-0.87; p<0.05)
having Positive Predictive Value (PPV) and Negative Predictive
Value (NPV) of 90.43% and 73.81%, respectively. Multiple
logistic regression model adjusted for age, weight, and duration
of stay to predict the outcome of SIRS, positive blood culture
and fatality case rate derived a significant association of PCT
with Odds Ratio (OR) being 1.23 (1.11-2.31), 1.06 (1.01-1.98)
and 1.76 (1.08-2.14), respectively.
Conclusion: Early identification and treatment for sepsis
significantly affects mortality. It appears that consecutive
measurements of biomarkers could be valuable, but further
prospective studies are important to characterise the role of
PCT as a prognostic marker in sepsis and severe sepsis. |
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| ISSN: | 2249-782X 0973-709X |