Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis
<i>Rosa gallica</i> is a widely used Rosa species for medicinal and culinary purposes. <i>Rosa gallica</i> has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of <i>Rosa gallica</i> against skin aging in v...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1663 |
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| author | Seongin Jo Young-Sung Jung Ye-Ryeong Cho Ji-Won Seo Won-Chul Lim Tae-Gyu Nam Tae-Gyu Lim Sanguine Byun |
| author_facet | Seongin Jo Young-Sung Jung Ye-Ryeong Cho Ji-Won Seo Won-Chul Lim Tae-Gyu Nam Tae-Gyu Lim Sanguine Byun |
| author_sort | Seongin Jo |
| collection | DOAJ |
| description | <i>Rosa gallica</i> is a widely used Rosa species for medicinal and culinary purposes. <i>Rosa gallica</i> has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of <i>Rosa gallica</i> against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of <i>Rosa gallica</i> prevented UVB−mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that <i>Rosa gallica</i> downregulates UVB−induced COX−2 and MMP−1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC−MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by <i>Rosa gallica</i>. Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c−Raf/MEK/ERK/c−Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB−induced MMP−1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, <i>Rosa gallica</i> could be used as a functional ingredient in the development of nutraceuticals against skin aging. |
| first_indexed | 2024-03-10T05:45:40Z |
| format | Article |
| id | doaj.art-e9b41b51f7b146d58ed0ef01fa642f75 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:40Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e9b41b51f7b146d58ed0ef01fa642f752023-11-22T22:11:51ZengMDPI AGAntioxidants2076-39212021-10-011011166310.3390/antiox10111663Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling AxisSeongin Jo0Young-Sung Jung1Ye-Ryeong Cho2Ji-Won Seo3Won-Chul Lim4Tae-Gyu Nam5Tae-Gyu Lim6Sanguine Byun7Department of Biotechnology, Yonsei University, Seoul 03722, KoreaKorea Food Research Institute, Wanju-gun 55365, KoreaDepartment of Biotechnology, Yonsei University, Seoul 03722, KoreaDepartment of Agricultural Biotechnology and Research, Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, KoreaKorea Food Research Institute, Wanju-gun 55365, KoreaMajor of Food Science and Biotechnology, Division of Bio-Convergence, Kyonggi University, Suwon 16227, KoreaKorea Food Research Institute, Wanju-gun 55365, KoreaDepartment of Biotechnology, Yonsei University, Seoul 03722, Korea<i>Rosa gallica</i> is a widely used Rosa species for medicinal and culinary purposes. <i>Rosa gallica</i> has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of <i>Rosa gallica</i> against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of <i>Rosa gallica</i> prevented UVB−mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that <i>Rosa gallica</i> downregulates UVB−induced COX−2 and MMP−1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC−MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by <i>Rosa gallica</i>. Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c−Raf/MEK/ERK/c−Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB−induced MMP−1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, <i>Rosa gallica</i> could be used as a functional ingredient in the development of nutraceuticals against skin aging.https://www.mdpi.com/2076-3921/10/11/1663<i>Rosa gallica</i>skin aginggallic acidc−RafUHPLC−MS/MS |
| spellingShingle | Seongin Jo Young-Sung Jung Ye-Ryeong Cho Ji-Won Seo Won-Chul Lim Tae-Gyu Nam Tae-Gyu Lim Sanguine Byun Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis Antioxidants <i>Rosa gallica</i> skin aging gallic acid c−Raf UHPLC−MS/MS |
| title | Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis |
| title_full | Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis |
| title_fullStr | Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis |
| title_full_unstemmed | Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis |
| title_short | Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis |
| title_sort | oral administration of i rosa gallica i prevents uvb induced skin aging through targeting the c raf signaling axis |
| topic | <i>Rosa gallica</i> skin aging gallic acid c−Raf UHPLC−MS/MS |
| url | https://www.mdpi.com/2076-3921/10/11/1663 |
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