Oral Immunization with <i>Escherichia coli Nissle 1917</i> Expressing SARS-CoV-2 Spike Protein Induces Mucosal and Systemic Antibody Responses in Mice

Oral Immunization with <i>Escherichia coli Nissle 1917</i> Expressing SARS-CoV-2 Spike Protein Induces Mucosal and Systemic Antibody Responses in Mice

As of October 2022, the COVID-19 pandemic continues to pose a major public health conundrum, with increased rates of symptomatic infections in vaccinated individuals. An ideal vaccine candidate for the prevention of outbreaks should be rapidly scalable, easy to administer, and able to elicit a poten...

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Bibliographic Details
Main Authors: Giovanni Sarnelli, Alessandro Del Re, Marcella Pesce, Jie Lu, Giovanni Esposito, Walter Sanseverino, Chiara Corpetti, Silvia Basili Franzin, Luisa Seguella, Irene Palenca, Sara Rurgo, Fatima Domenica Elisa De Palma, Aurora Zilli, Giuseppe Esposito
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomolecules
Subjects:
COVID-19
engineered probiotics
oral vaccine
IgA
Online Access:https://www.mdpi.com/2218-273X/13/3/569

Internet

https://www.mdpi.com/2218-273X/13/3/569

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