Associations Between the Kynurenine Pathway, Proinflammatory Cytokines, and Brain-Derived Neurotrophic Factor in Hospitalized Patients With Chronic Schizophrenia: A Preliminary Study

Associations Between the Kynurenine Pathway, Proinflammatory Cytokines, and Brain-Derived Neurotrophic Factor in Hospitalized Patients With Chronic Schizophrenia: A Preliminary Study

Purpose: The kynurenine (Kyn) pathway may play a role in the pathophysiology of schizophrenia. This pathway shows crosstalk with proinflammatory cytokines, including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), and/or brain-derived neurotrophic factor (BDNF). Moreover, Kyn meta...

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Bibliographic Details
Main Authors: Naomichi Okamoto, Tomoya Natsuyama, Ryohei Igata, Yuki Konishi, Hirofumi Tesen, Atsuko Ikenouchi, Reiji Yoshimura
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Psychiatry
Subjects:
schizophrenia
kynurenine pathway
kynurenine
quinolinic acid
inflammatory cytokines
BDNF
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.696059/full

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