Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa
Next-generation and Sanger sequencing were combined to identify disease-causing USH2A mutations in an adult patient with autosomal recessive RP. Induced pluripotent stem cells (iPSCs), generated from the patient’s keratinocytes, were differentiated into multi-layer eyecup-like structures with featur...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/00824 |