Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
AIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA). METHODS: In a retrospective study, UWFA images were obtained using an ultra-widefield imaging device in 42 normal eyes of 42 patients. Central and peripheral steered images were used to de...
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Press of International Journal of Ophthalmology (IJO PRESS)
2021-12-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2021/12/20211216.pdf |
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| author | Jing-Wen Jiang Zuo-Hui-Zi Yi Xiao-Ling Wang Jue-Jun Liu Gong-Peng Sun Chang-Zheng Chen |
| author_facet | Jing-Wen Jiang Zuo-Hui-Zi Yi Xiao-Ling Wang Jue-Jun Liu Gong-Peng Sun Chang-Zheng Chen |
| author_sort | Jing-Wen Jiang |
| collection | DOAJ |
| description | AIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA). METHODS: In a retrospective study, UWFA images were obtained using an ultra-widefield imaging device in 42 normal eyes of 42 patients. Central and peripheral steered images were used to define the edge of retinal vasculature by a certified grader. The length from the center of the optic disc to the edge of retinal vascularity (RVL) in each quadrant and the total retinal vascular perfusion area (RVPA) were determined by the grader using OptosAdvance software. The density of retinal vascularity (RVD) was quantified in different zones of central-steered images using Image J software. RESULTS: Among 42 healthy eyes, the values for mean RVL in each quadrant were 19.007±0.781 mm (superior), 18.467±0.869 mm (inferior), 17.738±0.622 mm (nasal) and 24.241±1.336 mm (temporal). The mean RVPA was 1140.117±73.825 mm2. The mean RVD of the total retina was 4.850%±0.638%. RVD varied significantly between different retina zones (P<0.001), and significant differences existed in the RVD values for total retinal area in patients over 50 years old compared to those under 50 years old (P=0.033). No gender difference was found. CONCLUSION: The UWFA device can be a promising tool for analyzing the overall retinal vasculature and may provide a better understanding of retinal vascular morphology in normal eyes. Aging may be related to lower RVD. |
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| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-21T09:37:18Z |
| publishDate | 2021-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-e9b6554968f6479cbaec85c590799ffa2022-12-21T19:08:36ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982021-12-0114121915192010.18240/ijo.2021.12.1620211216Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiographyJing-Wen Jiang0Zuo-Hui-Zi Yi1Xiao-Ling Wang2Jue-Jun Liu3Gong-Peng Sun4Chang-Zheng Chen5Chang-Zheng Chen. Renmin Hospital of Wuhan University, No.9 ZhangZhiDong Street, Wuchang District, Wuhan 430060, Hubei Province, China. whuchenchzh@163.comEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaAIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA). METHODS: In a retrospective study, UWFA images were obtained using an ultra-widefield imaging device in 42 normal eyes of 42 patients. Central and peripheral steered images were used to define the edge of retinal vasculature by a certified grader. The length from the center of the optic disc to the edge of retinal vascularity (RVL) in each quadrant and the total retinal vascular perfusion area (RVPA) were determined by the grader using OptosAdvance software. The density of retinal vascularity (RVD) was quantified in different zones of central-steered images using Image J software. RESULTS: Among 42 healthy eyes, the values for mean RVL in each quadrant were 19.007±0.781 mm (superior), 18.467±0.869 mm (inferior), 17.738±0.622 mm (nasal) and 24.241±1.336 mm (temporal). The mean RVPA was 1140.117±73.825 mm2. The mean RVD of the total retina was 4.850%±0.638%. RVD varied significantly between different retina zones (P<0.001), and significant differences existed in the RVD values for total retinal area in patients over 50 years old compared to those under 50 years old (P=0.033). No gender difference was found. CONCLUSION: The UWFA device can be a promising tool for analyzing the overall retinal vasculature and may provide a better understanding of retinal vascular morphology in normal eyes. Aging may be related to lower RVD.http://ies.ijo.cn/en_publish/2021/12/20211216.pdfultra-widefield fluorescein angiographyretinalvasculatureimaging |
| spellingShingle | Jing-Wen Jiang Zuo-Hui-Zi Yi Xiao-Ling Wang Jue-Jun Liu Gong-Peng Sun Chang-Zheng Chen Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography International Journal of Ophthalmology ultra-widefield fluorescein angiography retinal vasculature imaging |
| title | Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography |
| title_full | Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography |
| title_fullStr | Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography |
| title_full_unstemmed | Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography |
| title_short | Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography |
| title_sort | quantitative analysis of retinal vasculature in normal eyes using ultra widefield fluorescein angiography |
| topic | ultra-widefield fluorescein angiography retinal vasculature imaging |
| url | http://ies.ijo.cn/en_publish/2021/12/20211216.pdf |
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