Effects of combined 5-Fluorouracil and ZnO NPs on human breast cancer MCF-7 Cells: P53 gene expression, Bcl-2 signaling pathway, and invasion activity

Effects of combined 5-Fluorouracil and ZnO NPs on human breast cancer MCF-7 Cells: P53 gene expression, Bcl-2 signaling pathway, and invasion activity

Objective(s): The significant contribution of nanoparticles to cancer treatment has attracted therapeutic attention. The present study aimed to evaluate the synergistic effects of 5-fluorouracil (5-FU) and zinc oxide nanoparticles (ZnO NPs) as multimodal drug delivery on human breast cancer MCF-7 cel...

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Bibliographic Details
Main Authors: Safoura Hoseinzadeh, Elham Raeisi, Yves Lemoigne, Esfandiar Heidarian
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-07-01
Series:Nanomedicine Journal
Subjects:
Bcl-2
p53 expression
Zinc oxide naoparticles
5-fluorouracil
Online Access:http://nmj.mums.ac.ir/article_13111_60382b380848d83580e1426dce38618b.pdf

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