Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field
Objectives:The full-field stimulus threshold (FST) test was developed to evaluate the efficacy and safety of treatments of hereditary retinal diseases. In this study we performed the FST test in patients with retinitis pigmentosa (RP) and compared the results with findings from other ophthalmologica...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2024-02-01
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| Series: | Türk Oftalmoloji Dergisi |
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http://www.oftalmoloji.org/archives/archive-detail/article-preview/evaluation-of-full-field-stimulus-threshold-test-r/64471
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| _version_ | 1797293900079038464 |
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| author | Ayşe Öner Neslihan Sinim Kahraman |
| author_facet | Ayşe Öner Neslihan Sinim Kahraman |
| author_sort | Ayşe Öner |
| collection | DOAJ |
| description | Objectives:The full-field stimulus threshold (FST) test was developed to evaluate the efficacy and safety of treatments of hereditary retinal diseases. In this study we performed the FST test in patients with retinitis pigmentosa (RP) and compared the results with findings from other ophthalmological tests.Materials and Methods:The study included 51 intermediate and advanced RP patients and 21 normal subjects. All patients and controls underwent routine examination and ophthalmological tests including visual field, optical coherence tomography, full-field and multifocal electroretinography (mfERG), and FST tests. During FST testing, the perception thresholds of retina to the white, blue, and red FST were determined in decibels.Results:The mean age of the patients and the controls were 35.2 and 33.5 years, respectively. For all RP patients, no response was obtained on full-field ERG. All subjects were able to perform reliable FST tests. The mean values of visual acuity and central macular thickness were significantly lower and visual field mean deviation values were significantly higher in the RP group than the controls. When we evaluated the mfERG findings, the mean P1 wave amplitudes in all rings were significantly lower and the mean peak times were significantly longer in RP patients than controls. In comparisons of FST test results, the mean values for white, blue, red and the difference between blue-red thresholds were significantly lower in the RP group than the control group.Conclusion:The FST test is a fast and a reliable exam which can be done in subjects with poor visual acuity and reduced visual field. The results of this study confirm that the FST test can measure retinal sensitivity in severely affected RP subjects with flat flash ERG. |
| first_indexed | 2024-03-07T21:22:27Z |
| format | Article |
| id | doaj.art-e9b760cd766a4320904da4e88838dd2d |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-03-07T21:22:27Z |
| publishDate | 2024-02-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-e9b760cd766a4320904da4e88838dd2d2024-02-27T10:28:09ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612024-02-01541233110.4274/tjo.galenos.2023.5848513049054Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual FieldAyşe Öner0Neslihan Sinim Kahraman1 Acıbadem Sağlık Grubu, Taksim Hastanesi, Göz Hastalıkları Kliniği, İstanbul, Türkiye Acıbadem Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Optisyenlik Bölümü, İstanbul, Türkiye Objectives:The full-field stimulus threshold (FST) test was developed to evaluate the efficacy and safety of treatments of hereditary retinal diseases. In this study we performed the FST test in patients with retinitis pigmentosa (RP) and compared the results with findings from other ophthalmological tests.Materials and Methods:The study included 51 intermediate and advanced RP patients and 21 normal subjects. All patients and controls underwent routine examination and ophthalmological tests including visual field, optical coherence tomography, full-field and multifocal electroretinography (mfERG), and FST tests. During FST testing, the perception thresholds of retina to the white, blue, and red FST were determined in decibels.Results:The mean age of the patients and the controls were 35.2 and 33.5 years, respectively. For all RP patients, no response was obtained on full-field ERG. All subjects were able to perform reliable FST tests. The mean values of visual acuity and central macular thickness were significantly lower and visual field mean deviation values were significantly higher in the RP group than the controls. When we evaluated the mfERG findings, the mean P1 wave amplitudes in all rings were significantly lower and the mean peak times were significantly longer in RP patients than controls. In comparisons of FST test results, the mean values for white, blue, red and the difference between blue-red thresholds were significantly lower in the RP group than the control group.Conclusion:The FST test is a fast and a reliable exam which can be done in subjects with poor visual acuity and reduced visual field. The results of this study confirm that the FST test can measure retinal sensitivity in severely affected RP subjects with flat flash ERG. http://www.oftalmoloji.org/archives/archive-detail/article-preview/evaluation-of-full-field-stimulus-threshold-test-r/64471 full-field electroretinographyfull-field stimulus threshold testvisual fieldmultifocal electroretinographyoptical coherence tomographyretinitis pigmentosa |
| spellingShingle | Ayşe Öner Neslihan Sinim Kahraman Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field Türk Oftalmoloji Dergisi full-field electroretinography full-field stimulus threshold test visual field multifocal electroretinography optical coherence tomography retinitis pigmentosa |
| title | Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field |
| title_full | Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field |
| title_fullStr | Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field |
| title_full_unstemmed | Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field |
| title_short | Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field |
| title_sort | evaluation of full field stimulus threshold test results in retinitis pigmentosa relationship with full field electroretinography multifocal electroretinography optical coherence tomography and visual field |
| topic | full-field electroretinography full-field stimulus threshold test visual field multifocal electroretinography optical coherence tomography retinitis pigmentosa |
| url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/evaluation-of-full-field-stimulus-threshold-test-r/64471
|
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