Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus
The popularity of low-carbohydrate diets (LCDs) in the last few decades has motivated several research studies on their role in a variety of metabolic and non-morbid conditions. The available data of the results of these studies are put under the research perspective of the present literature review...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/240 |
| _version_ | 1797619413073002496 |
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| author | Eleni Pavlidou Sousana K. Papadopoulou Aristeidis Fasoulas Maria Mantzorou Constantinos Giaginis |
| author_facet | Eleni Pavlidou Sousana K. Papadopoulou Aristeidis Fasoulas Maria Mantzorou Constantinos Giaginis |
| author_sort | Eleni Pavlidou |
| collection | DOAJ |
| description | The popularity of low-carbohydrate diets (LCDs) in the last few decades has motivated several research studies on their role in a variety of metabolic and non-morbid conditions. The available data of the results of these studies are put under the research perspective of the present literature review of clinical studies in search of the effects of LCDs on Obesity and Diabetes Mellitus. The electronic literature search was performed in the databases PubMed, Cochrane, and Embase. The literature search found seven studies that met the review’s inclusion and exclusion criteria out of a total of 2637 studies. The included studies involved randomized controlled trials of at least 12 weeks’ duration, in subjects with BMI ≥ 25 kg/m<sup>2</sup>, with dietary interventions. The results of the study on the effects of LCDs on obesity showed their effectiveness in reducing Body Mass Index and total body fat mass. In addition, LCDs appear to cause drops in blood pressure, low-density lipoprotein (LDL), and triglycerides, and seem to improve high-density lipoprotein (HDL) values. Regarding the effectiveness of LCDs in Diabetes Mellitus, their effect on reducing insulin resistance and fasting blood glucose and HbA1c values are supported. In conclusion, the results suggest the critical role of LCDs to improve the health of people affected by obesity or diabetes. |
| first_indexed | 2024-03-11T08:26:44Z |
| format | Article |
| id | doaj.art-e9b762c1bcc848ba9c497e58785a5c67 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:44Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-e9b762c1bcc848ba9c497e58785a5c672023-11-16T22:04:50ZengMDPI AGMetabolites2218-19892023-02-0113224010.3390/metabo13020240Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes MellitusEleni Pavlidou0Sousana K. Papadopoulou1Aristeidis Fasoulas2Maria Mantzorou3Constantinos Giaginis4Department of Food Science and Nutrition, School of Environment, University of the Aegean, 81400 Myrina, GreeceDepartment of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57001 Thessaloniki, GreeceDepartment of Food Science and Nutrition, School of Environment, University of the Aegean, 81400 Myrina, GreeceDepartment of Food Science and Nutrition, School of Environment, University of the Aegean, 81400 Myrina, GreeceDepartment of Food Science and Nutrition, School of Environment, University of the Aegean, 81400 Myrina, GreeceThe popularity of low-carbohydrate diets (LCDs) in the last few decades has motivated several research studies on their role in a variety of metabolic and non-morbid conditions. The available data of the results of these studies are put under the research perspective of the present literature review of clinical studies in search of the effects of LCDs on Obesity and Diabetes Mellitus. The electronic literature search was performed in the databases PubMed, Cochrane, and Embase. The literature search found seven studies that met the review’s inclusion and exclusion criteria out of a total of 2637 studies. The included studies involved randomized controlled trials of at least 12 weeks’ duration, in subjects with BMI ≥ 25 kg/m<sup>2</sup>, with dietary interventions. The results of the study on the effects of LCDs on obesity showed their effectiveness in reducing Body Mass Index and total body fat mass. In addition, LCDs appear to cause drops in blood pressure, low-density lipoprotein (LDL), and triglycerides, and seem to improve high-density lipoprotein (HDL) values. Regarding the effectiveness of LCDs in Diabetes Mellitus, their effect on reducing insulin resistance and fasting blood glucose and HbA1c values are supported. In conclusion, the results suggest the critical role of LCDs to improve the health of people affected by obesity or diabetes.https://www.mdpi.com/2218-1989/13/2/240obesitylow-carbohydrate dietdiabetes mellitushealthy dietweight controlglucose |
| spellingShingle | Eleni Pavlidou Sousana K. Papadopoulou Aristeidis Fasoulas Maria Mantzorou Constantinos Giaginis Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus Metabolites obesity low-carbohydrate diet diabetes mellitus healthy diet weight control glucose |
| title | Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus |
| title_full | Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus |
| title_fullStr | Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus |
| title_full_unstemmed | Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus |
| title_short | Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus |
| title_sort | clinical evidence of low carbohydrate diets against obesity and diabetes mellitus |
| topic | obesity low-carbohydrate diet diabetes mellitus healthy diet weight control glucose |
| url | https://www.mdpi.com/2218-1989/13/2/240 |
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