Do Anti-Oxidants Vitamin D3, Melatonin, and Alpha-Lipoic Acid Have Synergistic Effects with Temozolomide on Cultured Glioblastoma Cells?

Do Anti-Oxidants Vitamin D3, Melatonin, and Alpha-Lipoic Acid Have Synergistic Effects with Temozolomide on Cultured Glioblastoma Cells?

Background: Cancer patients often take over-the-counter anti-oxidants as primary treatment or in combination with chemotherapy. Data about such use in glioblastoma is limited. Methods: Cultured U87-MG cells, a primary glioblastoma cell line (MU1454), U87-MG derived stem-like cells (scU87), and MU145...

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Bibliographic Details
Main Authors: Diane D. McConnell, Joe W. McGreevy, Macy N. Williams, N. Scott Litofsky
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Medicines
Subjects:
glioblastoma
antioxidant therapy
vitamin D3
melatonin
lipoic acid
Temozolomide
MTT
oxidative stress
neural stem cells
Online Access:http://www.mdpi.com/2305-6320/5/2/58

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