Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in Apc Min/+ mice

Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in Apc Min/+ mice

Abstract Background As a first-line chemotherapeutic agent, 5-fluorouracil (5-FU) exhibits many side effects, weakening its efficacy in cancer treatment. In this study, we hypothesize that Poria cocos polysaccharides (PCP), a traditional Chinese herbal medicine with various bioactivities and prebiot...

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Bibliographic Details
Main Authors: Lin Yin, Guoxin Huang, Imran Khan, Lu Su, Wenrui Xia, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Qiang Wu, Jingyi Wang, Wai Kit Leong, W. L. Wendy Hsiao
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Chinese Medicine
Subjects:
Poria cocos polysaccharides
5-fluorouracil
Colonic cancer
Gut microbiota
Online Access:https://doi.org/10.1186/s13020-022-00667-8

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