Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation
Myocarditis is a rare complication of Coronavirus Disease 2019 (COVID-19) vaccination. We report a case of an elderly female who presented initially with acute myocarditis, fulminant heart failure, and atrial fibrillation after receiving a modified ribonucleic acid (mRNA) vaccine (BNT162b2). Unlike...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1066699/full |
| _version_ | 1797870487863296000 |
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| author | Mi Zhou Chun Ka Wong Wan Yin Winnie Yeung Chung Wah Siu Lixue Yin |
| author_facet | Mi Zhou Chun Ka Wong Wan Yin Winnie Yeung Chung Wah Siu Lixue Yin |
| author_sort | Mi Zhou |
| collection | DOAJ |
| description | Myocarditis is a rare complication of Coronavirus Disease 2019 (COVID-19) vaccination. We report a case of an elderly female who presented initially with acute myocarditis, fulminant heart failure, and atrial fibrillation after receiving a modified ribonucleic acid (mRNA) vaccine (BNT162b2). Unlike other patients with vaccine-induced myocarditis, she developed persistent fever, sore throat, polyarthralgia, diffuse macular rash, and lymphadenopathy. After extensive investigation, she was diagnosed with post-vaccination Adult-Onset Still's Disease. The systemic inflammation gradually subsided after the use of non-steroidal anti-inflammatory drugs and systemic steroids. She was discharged from hospital with stable hemodynamics. Methotrexate was subsequently given to maintain long-term remission. |
| first_indexed | 2024-04-10T00:28:12Z |
| format | Article |
| id | doaj.art-e9bc2fb791de4ea494f972c4d6dcc554 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T00:28:12Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e9bc2fb791de4ea494f972c4d6dcc5542023-03-15T05:37:54ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.10666991066699Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentationMi Zhou0Chun Ka Wong1Wan Yin Winnie Yeung2Chung Wah Siu3Lixue Yin4Cardiology Division, Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaCardiology Division, Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaRheumatology Division, Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong SAR, ChinaCardiology Division, Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaCardiovascular Ultrasound and Non-Invasive Cardiology Department, Sichuan Provincial People's Hospital, Chengdu, ChinaMyocarditis is a rare complication of Coronavirus Disease 2019 (COVID-19) vaccination. We report a case of an elderly female who presented initially with acute myocarditis, fulminant heart failure, and atrial fibrillation after receiving a modified ribonucleic acid (mRNA) vaccine (BNT162b2). Unlike other patients with vaccine-induced myocarditis, she developed persistent fever, sore throat, polyarthralgia, diffuse macular rash, and lymphadenopathy. After extensive investigation, she was diagnosed with post-vaccination Adult-Onset Still's Disease. The systemic inflammation gradually subsided after the use of non-steroidal anti-inflammatory drugs and systemic steroids. She was discharged from hospital with stable hemodynamics. Methotrexate was subsequently given to maintain long-term remission.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1066699/fullmyocarditisvaccinemRNA vaccineAdult-Onset Still's Disease (AOSD)autoimmune disease |
| spellingShingle | Mi Zhou Chun Ka Wong Wan Yin Winnie Yeung Chung Wah Siu Lixue Yin Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation Frontiers in Cardiovascular Medicine myocarditis vaccine mRNA vaccine Adult-Onset Still's Disease (AOSD) autoimmune disease |
| title | Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation |
| title_full | Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation |
| title_fullStr | Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation |
| title_full_unstemmed | Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation |
| title_short | Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation |
| title_sort | case report coronavirus disease 2019 covid 19 modified rna vaccination induced adult onset still s disease with fulminant myocarditis as initial presentation |
| topic | myocarditis vaccine mRNA vaccine Adult-Onset Still's Disease (AOSD) autoimmune disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1066699/full |
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