Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
Podocytes are essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to proteinuric kidney disease. Here Liu et al. show that Sirt6 protects podocytes from apoptosis and inflammation by increasing autophagic flux through inhibition of the Notch pathway.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00498-4 |
| _version_ | 1818343351963877376 |
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| author | Min Liu Kaili Liang Junhui Zhen Meng Zhou Xiaojie Wang Ziying Wang Xinbing Wei Yan Zhang Yu Sun Zhuanli Zhou Hua Su Chun Zhang Ningjun Li Chengjiang Gao Jun Peng Fan Yi |
| author_facet | Min Liu Kaili Liang Junhui Zhen Meng Zhou Xiaojie Wang Ziying Wang Xinbing Wei Yan Zhang Yu Sun Zhuanli Zhou Hua Su Chun Zhang Ningjun Li Chengjiang Gao Jun Peng Fan Yi |
| author_sort | Min Liu |
| collection | DOAJ |
| description | Podocytes are essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to proteinuric kidney disease. Here Liu et al. show that Sirt6 protects podocytes from apoptosis and inflammation by increasing autophagic flux through inhibition of the Notch pathway. |
| first_indexed | 2024-12-13T16:29:13Z |
| format | Article |
| id | doaj.art-e9bf4989decc4c6c98bc0fee37feaa6d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:29:13Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e9bf4989decc4c6c98bc0fee37feaa6d2022-12-21T23:38:33ZengNature PortfolioNature Communications2041-17232017-09-018111510.1038/s41467-017-00498-4Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signalingMin Liu0Kaili Liang1Junhui Zhen2Meng Zhou3Xiaojie Wang4Ziying Wang5Xinbing Wei6Yan Zhang7Yu Sun8Zhuanli Zhou9Hua Su10Chun Zhang11Ningjun Li12Chengjiang Gao13Jun Peng14Fan Yi15Department of Pharmacology, Shandong University School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDepartment of Pathology, Shandong University School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth UniversityDepartment of Immunology, Shandong University School of MedicineDepartment of Hematology, Qilu Hospital, Shandong UniversityDepartment of Pharmacology, Shandong University School of MedicinePodocytes are essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to proteinuric kidney disease. Here Liu et al. show that Sirt6 protects podocytes from apoptosis and inflammation by increasing autophagic flux through inhibition of the Notch pathway.https://doi.org/10.1038/s41467-017-00498-4 |
| spellingShingle | Min Liu Kaili Liang Junhui Zhen Meng Zhou Xiaojie Wang Ziying Wang Xinbing Wei Yan Zhang Yu Sun Zhuanli Zhou Hua Su Chun Zhang Ningjun Li Chengjiang Gao Jun Peng Fan Yi Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling Nature Communications |
| title | Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling |
| title_full | Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling |
| title_fullStr | Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling |
| title_full_unstemmed | Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling |
| title_short | Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling |
| title_sort | sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting notch signaling |
| url | https://doi.org/10.1038/s41467-017-00498-4 |
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