The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers
Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses. The New World arenaviruses comprise four clades: А, B, C, D; pathogenic for humans New World arenaviruses are attri...
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2018-07-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/476 |
| _version_ | 1797220838222594048 |
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| author | T. E. Sizikova V. N. Lebedev S. I. Syromyatnikova S. V. Borisevich |
| author_facet | T. E. Sizikova V. N. Lebedev S. I. Syromyatnikova S. V. Borisevich |
| author_sort | T. E. Sizikova |
| collection | DOAJ |
| description | Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses. The New World arenaviruses comprise four clades: А, B, C, D; pathogenic for humans New World arenaviruses are attributed to clade B. Lassa, Lujo, Machupo, Junin, Guanarito and Sabia viruses are the agents of extremely hazardous hemorrhagic fevers (Lassa hemorrhagic fever, Lujo hemorrhagic fever, Bolivian hemorrhagic fever, Argentinean hemorrhagic fever, Venezuelan hemorrhagic fever, Brazilian hemorrhagic fever, accordingly). These arenaviruses pose a potential threat to national public health due to the possibility of their accidental importation into the territory of the Russian Federation. The vaccination of risk group is the most effective and money-saving means of protection against epidemic spread. Objective of this review is to analyze the specific preparations for arenaviral hemorrhagic fever prevention that are currently under development. Production of live vaccines based on attenuated strains of the agents, the DNA vaccines, vector recombinant vaccines and vaccines on the basis of RNA-replicons is viewed as the main trends in the area. Тhe most important results in the development of effective prophylactic means against arenaviral hemorrhagic fevers are discussed in this paper. |
| first_indexed | 2024-03-08T13:42:59Z |
| format | Article |
| id | doaj.art-e9c15123a93e40d58ffb19f3cbeea728 |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:55:54Z |
| publishDate | 2018-07-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-e9c15123a93e40d58ffb19f3cbeea7282024-04-05T16:47:13ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2018-07-0102303610.21055/0370-1069-2018-2-30-36465The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic FeversT. E. Sizikova0V. N. Lebedev1S. I. Syromyatnikova2S. V. Borisevich3Federal State Budgetary Institution «48th Central Research Institute» of the Ministry of Defense of the Russian Federation, Sergiev PossadFederal State Budgetary Institution «48th Central Research Institute» of the Ministry of Defense of the Russian Federation, Sergiev PossadFederal State Budgetary Institution «48th Central Research Institute» of the Ministry of Defense of the Russian Federation, Sergiev PossadFederal State Budgetary Institution «48th Central Research Institute» of the Ministry of Defense of the Russian Federation, Sergiev PossadPresently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses. The New World arenaviruses comprise four clades: А, B, C, D; pathogenic for humans New World arenaviruses are attributed to clade B. Lassa, Lujo, Machupo, Junin, Guanarito and Sabia viruses are the agents of extremely hazardous hemorrhagic fevers (Lassa hemorrhagic fever, Lujo hemorrhagic fever, Bolivian hemorrhagic fever, Argentinean hemorrhagic fever, Venezuelan hemorrhagic fever, Brazilian hemorrhagic fever, accordingly). These arenaviruses pose a potential threat to national public health due to the possibility of their accidental importation into the territory of the Russian Federation. The vaccination of risk group is the most effective and money-saving means of protection against epidemic spread. Objective of this review is to analyze the specific preparations for arenaviral hemorrhagic fever prevention that are currently under development. Production of live vaccines based on attenuated strains of the agents, the DNA vaccines, vector recombinant vaccines and vaccines on the basis of RNA-replicons is viewed as the main trends in the area. Тhe most important results in the development of effective prophylactic means against arenaviral hemorrhagic fevers are discussed in this paper.https://journal.microbe.ru/jour/article/view/476hemorrhagic feversarenaviruseslassa virusmachupo virusjunin virusspecific prophylacticslive vaccinesvector recombinant vaccinesrna-repliconsdna vaccines |
| spellingShingle | T. E. Sizikova V. N. Lebedev S. I. Syromyatnikova S. V. Borisevich The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers Проблемы особо опасных инфекций hemorrhagic fevers arenaviruses lassa virus machupo virus junin virus specific prophylactics live vaccines vector recombinant vaccines rna-replicons dna vaccines |
| title | The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers |
| title_full | The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers |
| title_fullStr | The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers |
| title_full_unstemmed | The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers |
| title_short | The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers |
| title_sort | current state of vaccine development for specific prophylactics of arenaviral hemorrhagic fevers |
| topic | hemorrhagic fevers arenaviruses lassa virus machupo virus junin virus specific prophylactics live vaccines vector recombinant vaccines rna-replicons dna vaccines |
| url | https://journal.microbe.ru/jour/article/view/476 |
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