p53 expression in pterygium in two climatic regions in Turkey
<b>Purpose:</b> To assess accumulation of p53 protein in samples of primary pterygium from people living in two different climatic regions in Turkey. <b> Materials and Methods:</b> Group 1 included 101 pterygium specimens from people in Adana located in southern Turkey. Gro...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2009-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2009;volume=57;issue=3;spage=203;epage=206;aulast=Pelit |
| _version_ | 1818952805601247232 |
|---|---|
| author | Pelit Aysel Bal Nebil Akova Yonca Demirhan Beyhan |
| author_facet | Pelit Aysel Bal Nebil Akova Yonca Demirhan Beyhan |
| author_sort | Pelit Aysel |
| collection | DOAJ |
| description | <b>Purpose:</b> To assess accumulation of p53 protein in samples of primary pterygium from people living in two different climatic regions in Turkey. <b> Materials and Methods:</b> Group 1 included 101 pterygium specimens from people in Adana located in southern Turkey. Group 2 included 39 pterygium specimens from people in Ankara, located in the middle of Turkey. Climatic conditions throughout the year are sunnier and warmer in Adana than they are in Ankara. The control group (Group 3)<b> </b> included 30 specimens of conjunctiva that had been excised during cataract surgery from 30 patients without pterygium. The pterygial specimens and control conjunctiva were studied by immunohistochemistry using antibodies against p53 protein. Pearson′s chi-square<sup> </sup> test was used to compare the p53 immunoreactivity. <b> Results:</b> The p53 immunoreactivity in Groups 1 and 2 was greater than it was in the control group (<i> P< </i> 0.001). There were no differences in p53 immunoreactivity between Groups 1 and 2 (<i> P= </i> 0.060). <b> Conclusion:</b> The p53 immunoreactivity was not correlated with ultraviolet irradiation exposure. The p53 immunoreactivity in our pterygium specimens suggests that pterygium could be a result of uncontrolled cell proliferation. |
| first_indexed | 2024-12-20T09:56:13Z |
| format | Article |
| id | doaj.art-e9c502efe117420fa1761252e8b32556 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-20T09:56:13Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-e9c502efe117420fa1761252e8b325562022-12-21T19:44:27ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892009-01-01573203206p53 expression in pterygium in two climatic regions in TurkeyPelit AyselBal NebilAkova YoncaDemirhan Beyhan<b>Purpose:</b> To assess accumulation of p53 protein in samples of primary pterygium from people living in two different climatic regions in Turkey. <b> Materials and Methods:</b> Group 1 included 101 pterygium specimens from people in Adana located in southern Turkey. Group 2 included 39 pterygium specimens from people in Ankara, located in the middle of Turkey. Climatic conditions throughout the year are sunnier and warmer in Adana than they are in Ankara. The control group (Group 3)<b> </b> included 30 specimens of conjunctiva that had been excised during cataract surgery from 30 patients without pterygium. The pterygial specimens and control conjunctiva were studied by immunohistochemistry using antibodies against p53 protein. Pearson′s chi-square<sup> </sup> test was used to compare the p53 immunoreactivity. <b> Results:</b> The p53 immunoreactivity in Groups 1 and 2 was greater than it was in the control group (<i> P< </i> 0.001). There were no differences in p53 immunoreactivity between Groups 1 and 2 (<i> P= </i> 0.060). <b> Conclusion:</b> The p53 immunoreactivity was not correlated with ultraviolet irradiation exposure. The p53 immunoreactivity in our pterygium specimens suggests that pterygium could be a result of uncontrolled cell proliferation.http://www.ijo.in/article.asp?issn=0301-4738;year=2009;volume=57;issue=3;spage=203;epage=206;aulast=PelitConjunctivapterygiumtumor supressor gene p53 |
| spellingShingle | Pelit Aysel Bal Nebil Akova Yonca Demirhan Beyhan p53 expression in pterygium in two climatic regions in Turkey Indian Journal of Ophthalmology Conjunctiva pterygium tumor supressor gene p53 |
| title | p53 expression in pterygium in two climatic regions in Turkey |
| title_full | p53 expression in pterygium in two climatic regions in Turkey |
| title_fullStr | p53 expression in pterygium in two climatic regions in Turkey |
| title_full_unstemmed | p53 expression in pterygium in two climatic regions in Turkey |
| title_short | p53 expression in pterygium in two climatic regions in Turkey |
| title_sort | p53 expression in pterygium in two climatic regions in turkey |
| topic | Conjunctiva pterygium tumor supressor gene p53 |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2009;volume=57;issue=3;spage=203;epage=206;aulast=Pelit |
| work_keys_str_mv | AT pelitaysel p53expressioninpterygiumintwoclimaticregionsinturkey AT balnebil p53expressioninpterygiumintwoclimaticregionsinturkey AT akovayonca p53expressioninpterygiumintwoclimaticregionsinturkey AT demirhanbeyhan p53expressioninpterygiumintwoclimaticregionsinturkey |