PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors
The tips of the developing respiratory buds are home to important progenitor cells marked by the expression of SOX9 and ID2. Early in embryonic development (prior to E13.5), SOX9+progenitors are multipotent, generating both airway and alveolar epithelium, but are selective progenitors of alveolar ep...
Main Authors: | Divya Khattar, Sharlene Fernandes, John Snowball, Minzhe Guo, Matthew C Gillen, Suchi Singh Jain, Debora Sinner, William Zacharias, Daniel T Swarr |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/67954 |
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