PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors

PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors

The tips of the developing respiratory buds are home to important progenitor cells marked by the expression of SOX9 and ID2. Early in embryonic development (prior to E13.5), SOX9+progenitors are multipotent, generating both airway and alveolar epithelium, but are selective progenitors of alveolar ep...

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Bibliographic Details
Main Authors: Divya Khattar, Sharlene Fernandes, John Snowball, Minzhe Guo, Matthew C Gillen, Suchi Singh Jain, Debora Sinner, William Zacharias, Daniel T Swarr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
chromatin accessibility
lung development
ATAC-Seq
lung distal tip progenitor cells
epigenomics
Online Access:https://elifesciences.org/articles/67954

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