Effect of hydroxyzine on pruritus of hemodialysis patients
Background: Uremic pruritus is one of the important problems in patients undergoing hemodialysis. Causing the mechanism of uremic pruritus in hemodialysis patients is complex and multifactorial. Almost 60 percent of hemodialysis patients suffer from uremic pruritus. Oral hydroxyzine is a common trea...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2020-05-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/article-1-10482-en.html |
| _version_ | 1818244720220962816 |
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| author | Mohsen Soleimani Rahimeh Nabavi Nadia Karimi Abbasali Ebrahimian |
| author_facet | Mohsen Soleimani Rahimeh Nabavi Nadia Karimi Abbasali Ebrahimian |
| author_sort | Mohsen Soleimani |
| collection | DOAJ |
| description | Background: Uremic pruritus is one of the important problems in patients undergoing hemodialysis. Causing the mechanism of uremic pruritus in hemodialysis patients is complex and multifactorial. Almost 60 percent of hemodialysis patients suffer from uremic pruritus. Oral hydroxyzine is a common treatment for uremic pruritus of this patients. This study aimed to survey effect of hydroxyzine on uremic pruritus of hemodialysis patients.
Methods: This quasi-experimental study (pre and post design) performed on 40 patients with eligible criteria. All of the hemodialysis patients who suffer from pruritus received a tablet of hydroxyzine 25 mg daily for 6 weeks. In this time, drugs and the plan of hemodialysis were constant. Pruritus score of patients, evaluated with 5-D pruritus scale that had 8 items with 5-score Likert scale and evaluate duration, direction, disability, and distribution of pruritus. Severity scores of pruritus before and after treatment with tablet of hydroxyzine were compared. This study was conducted on hemodialysis patients in the Soodeh Center of Hemodialysis in the south of Tehran, Iran, from September 2016 to February 2017.
Results: The findings of this study showed that most of the patients in this study were male (55%) with mean age of 55.97±11.59 years. The most cause of chronic renal failure in these patients was diabetes (37.5%). This study showed that 32.5% of the hemodialysis patients had moderate to severe uremic pruritus. The mean score of pruritus before the treatment with hydroxyzine was 16.73±3.4 and the most effect of this drug was in the social activity item (2.47±0.6). After treatment with hydroxyzine, the mean score of pruritus in the patients was 9.65±2.15 that was decreased significantly (P<0.001). The findings showed that there was no significant relationship between decrease of pruritus and characteristics of patients.
Conclusion: This study showed that uremic pruritus is still a challenge in hemodialysis patients. According to this study use of hydroxyzine, regardless of uremic pruritus mechanism, could be decreased uremic pruritus of hemodialysis patients. |
| first_indexed | 2024-12-12T14:21:30Z |
| format | Article |
| id | doaj.art-e9c8a393f34e4358bb8b029d08ae9d33 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-12T14:21:30Z |
| publishDate | 2020-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-e9c8a393f34e4358bb8b029d08ae9d332022-12-22T00:21:47ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222020-05-01783171177Effect of hydroxyzine on pruritus of hemodialysis patientsMohsen Soleimani0Rahimeh Nabavi1Nadia Karimi2Abbasali Ebrahimian3 Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran. Department of Critical Care Nursing and Emergency, Faculty of Nursing, Semnan University of Medical Sciences, Semnan, Iran. Department of Critical Care Nursing, Student Research Committee, Faculty of Nursing and Midwifery, Semnan University of Medical Sciences, Semnan, Iran. Department of Orology and Nephrology, Soodeh Dialysis Center, Islamshahr, Tehran, Iran. Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran. Department of Critical Care Nursing and Emergency, Faculty of Nursing, Semnan University of Medical Sciences, Semnan, Iran. Background: Uremic pruritus is one of the important problems in patients undergoing hemodialysis. Causing the mechanism of uremic pruritus in hemodialysis patients is complex and multifactorial. Almost 60 percent of hemodialysis patients suffer from uremic pruritus. Oral hydroxyzine is a common treatment for uremic pruritus of this patients. This study aimed to survey effect of hydroxyzine on uremic pruritus of hemodialysis patients. Methods: This quasi-experimental study (pre and post design) performed on 40 patients with eligible criteria. All of the hemodialysis patients who suffer from pruritus received a tablet of hydroxyzine 25 mg daily for 6 weeks. In this time, drugs and the plan of hemodialysis were constant. Pruritus score of patients, evaluated with 5-D pruritus scale that had 8 items with 5-score Likert scale and evaluate duration, direction, disability, and distribution of pruritus. Severity scores of pruritus before and after treatment with tablet of hydroxyzine were compared. This study was conducted on hemodialysis patients in the Soodeh Center of Hemodialysis in the south of Tehran, Iran, from September 2016 to February 2017. Results: The findings of this study showed that most of the patients in this study were male (55%) with mean age of 55.97±11.59 years. The most cause of chronic renal failure in these patients was diabetes (37.5%). This study showed that 32.5% of the hemodialysis patients had moderate to severe uremic pruritus. The mean score of pruritus before the treatment with hydroxyzine was 16.73±3.4 and the most effect of this drug was in the social activity item (2.47±0.6). After treatment with hydroxyzine, the mean score of pruritus in the patients was 9.65±2.15 that was decreased significantly (P<0.001). The findings showed that there was no significant relationship between decrease of pruritus and characteristics of patients. Conclusion: This study showed that uremic pruritus is still a challenge in hemodialysis patients. According to this study use of hydroxyzine, regardless of uremic pruritus mechanism, could be decreased uremic pruritus of hemodialysis patients.http://tumj.tums.ac.ir/article-1-10482-en.htmlchronic renal failurehemodialysishydroxyzinepruritus |
| spellingShingle | Mohsen Soleimani Rahimeh Nabavi Nadia Karimi Abbasali Ebrahimian Effect of hydroxyzine on pruritus of hemodialysis patients Tehran University Medical Journal chronic renal failure hemodialysis hydroxyzine pruritus |
| title | Effect of hydroxyzine on pruritus of hemodialysis patients |
| title_full | Effect of hydroxyzine on pruritus of hemodialysis patients |
| title_fullStr | Effect of hydroxyzine on pruritus of hemodialysis patients |
| title_full_unstemmed | Effect of hydroxyzine on pruritus of hemodialysis patients |
| title_short | Effect of hydroxyzine on pruritus of hemodialysis patients |
| title_sort | effect of hydroxyzine on pruritus of hemodialysis patients |
| topic | chronic renal failure hemodialysis hydroxyzine pruritus |
| url | http://tumj.tums.ac.ir/article-1-10482-en.html |
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