Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway optimization with minimal experimental resources.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11163 |
| _version_ | 1818342057154969600 |
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| author | Markus Jeschek Daniel Gerngross Sven Panke |
| author_facet | Markus Jeschek Daniel Gerngross Sven Panke |
| author_sort | Markus Jeschek |
| collection | DOAJ |
| description | Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway optimization with minimal experimental resources. |
| first_indexed | 2024-12-13T16:08:38Z |
| format | Article |
| id | doaj.art-e9c8e8a8f07c4ecbac79a4d985f6ac3a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:08:38Z |
| publishDate | 2016-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e9c8e8a8f07c4ecbac79a4d985f6ac3a2022-12-21T23:38:59ZengNature PortfolioNature Communications2041-17232016-03-017111010.1038/ncomms11163Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effortMarkus Jeschek0Daniel Gerngross1Sven Panke2Department of Biosystems Science and Engineering, ETH ZurichDepartment of Biosystems Science and Engineering, ETH ZurichDepartment of Biosystems Science and Engineering, ETH ZurichRational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway optimization with minimal experimental resources.https://doi.org/10.1038/ncomms11163 |
| spellingShingle | Markus Jeschek Daniel Gerngross Sven Panke Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort Nature Communications |
| title | Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort |
| title_full | Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort |
| title_fullStr | Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort |
| title_full_unstemmed | Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort |
| title_short | Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort |
| title_sort | rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort |
| url | https://doi.org/10.1038/ncomms11163 |
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