The Role of miR-29s in Human Cancers—An Update
MicroRNAs (miRNAs) are small non-coding RNAs that directly bind to the 3’ untranslated region (3’-UTR) of the target mRNAs to inhibit their expression. The miRNA-29s (miR-29s) are suggested to be either tumor suppressors or oncogenic miRNAs that are strongly dysregulated in various types of cancer....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/9/2121 |
| _version_ | 1797490976455917568 |
|---|---|
| author | Thuy T. P. Nguyen Kamrul Hassan Suman Thong Ba Nguyen Ha Thi Nguyen Duy Ngoc Do |
| author_facet | Thuy T. P. Nguyen Kamrul Hassan Suman Thong Ba Nguyen Ha Thi Nguyen Duy Ngoc Do |
| author_sort | Thuy T. P. Nguyen |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small non-coding RNAs that directly bind to the 3’ untranslated region (3’-UTR) of the target mRNAs to inhibit their expression. The miRNA-29s (miR-29s) are suggested to be either tumor suppressors or oncogenic miRNAs that are strongly dysregulated in various types of cancer. Their dysregulation alters the expression of their target genes, thereby exerting influence on different cellular pathways including cell proliferation, apoptosis, migration, and invasion, thereby contributing to carcinogenesis. In the present review, we aimed to provide an overview of the current knowledge on the miR-29s biological network and its functions in cancer, as well as its current and potential applications as a diagnostic and prognostic biomarker and/or a therapeutic target in major types of human cancer. |
| first_indexed | 2024-03-10T00:40:47Z |
| format | Article |
| id | doaj.art-e9c92cd1c60a43e292a84879ab5eabca |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:40:47Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e9c92cd1c60a43e292a84879ab5eabca2023-11-23T15:09:25ZengMDPI AGBiomedicines2227-90592022-08-01109212110.3390/biomedicines10092121The Role of miR-29s in Human Cancers—An UpdateThuy T. P. Nguyen0Kamrul Hassan Suman1Thong Ba Nguyen2Ha Thi Nguyen3Duy Ngoc Do4Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USADepartment of Fisheries, Ministry of Fisheries and Livestock, Dhaka 1205, BangladeshDepartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USAInstitute of Research and Development, Duy Tan University, Danang 550000, VietnamDepartment of Animal Science and Aquaculture, Dalhousie University, Truro, NS B2N 5E3, CanadaMicroRNAs (miRNAs) are small non-coding RNAs that directly bind to the 3’ untranslated region (3’-UTR) of the target mRNAs to inhibit their expression. The miRNA-29s (miR-29s) are suggested to be either tumor suppressors or oncogenic miRNAs that are strongly dysregulated in various types of cancer. Their dysregulation alters the expression of their target genes, thereby exerting influence on different cellular pathways including cell proliferation, apoptosis, migration, and invasion, thereby contributing to carcinogenesis. In the present review, we aimed to provide an overview of the current knowledge on the miR-29s biological network and its functions in cancer, as well as its current and potential applications as a diagnostic and prognostic biomarker and/or a therapeutic target in major types of human cancer.https://www.mdpi.com/2227-9059/10/9/2121cancermicroRNAmiR-29biomarkertherapeutic target |
| spellingShingle | Thuy T. P. Nguyen Kamrul Hassan Suman Thong Ba Nguyen Ha Thi Nguyen Duy Ngoc Do The Role of miR-29s in Human Cancers—An Update Biomedicines cancer microRNA miR-29 biomarker therapeutic target |
| title | The Role of miR-29s in Human Cancers—An Update |
| title_full | The Role of miR-29s in Human Cancers—An Update |
| title_fullStr | The Role of miR-29s in Human Cancers—An Update |
| title_full_unstemmed | The Role of miR-29s in Human Cancers—An Update |
| title_short | The Role of miR-29s in Human Cancers—An Update |
| title_sort | role of mir 29s in human cancers an update |
| topic | cancer microRNA miR-29 biomarker therapeutic target |
| url | https://www.mdpi.com/2227-9059/10/9/2121 |
| work_keys_str_mv | AT thuytpnguyen theroleofmir29sinhumancancersanupdate AT kamrulhassansuman theroleofmir29sinhumancancersanupdate AT thongbanguyen theroleofmir29sinhumancancersanupdate AT hathinguyen theroleofmir29sinhumancancersanupdate AT duyngocdo theroleofmir29sinhumancancersanupdate AT thuytpnguyen roleofmir29sinhumancancersanupdate AT kamrulhassansuman roleofmir29sinhumancancersanupdate AT thongbanguyen roleofmir29sinhumancancersanupdate AT hathinguyen roleofmir29sinhumancancersanupdate AT duyngocdo roleofmir29sinhumancancersanupdate |