Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges
Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting empl...
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| Format: | Article |
| Language: | English |
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Iranian Society of Nanomedicine
2019-09-01
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| Series: | Nanomedicine Research Journal |
| Subjects: | |
| Online Access: | http://www.nanomedicine-rj.com/article_36899_3938552e42b8d8b2c36d8824d8d5b252.pdf |
| _version_ | 1818207209621815296 |
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| author | Farnaz Fattahi Akbar Khoddami Ozan Avinc |
| author_facet | Farnaz Fattahi Akbar Khoddami Ozan Avinc |
| author_sort | Farnaz Fattahi |
| collection | DOAJ |
| description | Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in biomedical application owing to its well categorized biodegradable properties. PLA(−[CH(CH3)COO]n–)is linear biodegradable aliphatic polyester which can be derived from 100% renewable bioresources like rice and wheatthrough fermentation and polymerization. PLA has been accepted by FDA to be applied in biomaterials, such as sutures, bone plates, abdominal mesh, and drug delivery systems. <br /> PLA holds stereoisomers,for instancePoly(L-Lactide)(PLLA), Poly(D-Lactide) (PDLA), and Poly(DL-Lactide) (PDLLA). <br /> PLGA is a copolymer of PLA and Poly(Glycolic Acid) (PGA) that are most usually used biodegradable synthetic polymers for biomedical applications such as scaffolds and drug delivery systems<br /> The objective of this review paper is to highpoint the possibility of PLA nanofibres as drug deliverysubstances and to give full information about the newprogresses about the PLA , PLLA and PLGA nanofibers fabrication as noveldrug delivery systems. |
| first_indexed | 2024-12-12T04:25:17Z |
| format | Article |
| id | doaj.art-e9cd0762039f49e4ad4cc54a51eb94e9 |
| institution | Directory Open Access Journal |
| issn | 2476-3489 2476-7123 |
| language | English |
| last_indexed | 2024-12-12T04:25:17Z |
| publishDate | 2019-09-01 |
| publisher | Iranian Society of Nanomedicine |
| record_format | Article |
| series | Nanomedicine Research Journal |
| spelling | doaj.art-e9cd0762039f49e4ad4cc54a51eb94e92022-12-22T00:38:13ZengIranian Society of NanomedicineNanomedicine Research Journal2476-34892476-71232019-09-014313014010.22034/nmrj.2019.03.00236899Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and ChallengesFarnaz Fattahi0Akbar Khoddami1Ozan Avinc2Department of Textile Engineering, Isfahan University of Technology, Isfahan 84156-8311, IranDepartment of Textile Engineering, Isfahan University of Technology, Isfahan 84156-8311, IranDepartment of Textile Engineering, Pamukkale University, 20160, Denizli, TurkeyNumerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in biomedical application owing to its well categorized biodegradable properties. PLA(−[CH(CH3)COO]n–)is linear biodegradable aliphatic polyester which can be derived from 100% renewable bioresources like rice and wheatthrough fermentation and polymerization. PLA has been accepted by FDA to be applied in biomaterials, such as sutures, bone plates, abdominal mesh, and drug delivery systems. <br /> PLA holds stereoisomers,for instancePoly(L-Lactide)(PLLA), Poly(D-Lactide) (PDLA), and Poly(DL-Lactide) (PDLLA). <br /> PLGA is a copolymer of PLA and Poly(Glycolic Acid) (PGA) that are most usually used biodegradable synthetic polymers for biomedical applications such as scaffolds and drug delivery systems<br /> The objective of this review paper is to highpoint the possibility of PLA nanofibres as drug deliverysubstances and to give full information about the newprogresses about the PLA , PLLA and PLGA nanofibers fabrication as noveldrug delivery systems.http://www.nanomedicine-rj.com/article_36899_3938552e42b8d8b2c36d8824d8d5b252.pdfpoly (lactic acid) (pla)nanofibredrugdeliverycontrolled release |
| spellingShingle | Farnaz Fattahi Akbar Khoddami Ozan Avinc Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges Nanomedicine Research Journal poly (lactic acid) (pla) nanofibre drug delivery controlled release |
| title | Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges |
| title_full | Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges |
| title_fullStr | Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges |
| title_full_unstemmed | Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges |
| title_short | Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges |
| title_sort | poly lactic acid nanofibres as drug delivery systems opportunities and challenges |
| topic | poly (lactic acid) (pla) nanofibre drug delivery controlled release |
| url | http://www.nanomedicine-rj.com/article_36899_3938552e42b8d8b2c36d8824d8d5b252.pdf |
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