Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy
<i>Background and Objectives</i>: Cancer treatments can adversely influence body weight status, body composition, phase angle (PhA), and resting metabolic rate (RMR), which could possibly affect disease course. Τhe aim was to assess differences in body composition, PhA, RMR, and related...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/12/1779 |
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| author | Paraskevi Detopoulou Theodora Tsiouda Maria Pilikidou Foteini Palyvou Eirini Tsekitsidi Maria Mantzorou Persefoni Pezirkianidou Krystallia Kyrka Spyridon Methenitis Gavriela Voulgaridou Pavlos Zarogoulidis Rena Oikonomidou Dimitris Matthaios Κonstantinos Porpodis Dimitrios Giannakidis Sousana K. Papadopoulou |
| author_facet | Paraskevi Detopoulou Theodora Tsiouda Maria Pilikidou Foteini Palyvou Eirini Tsekitsidi Maria Mantzorou Persefoni Pezirkianidou Krystallia Kyrka Spyridon Methenitis Gavriela Voulgaridou Pavlos Zarogoulidis Rena Oikonomidou Dimitris Matthaios Κonstantinos Porpodis Dimitrios Giannakidis Sousana K. Papadopoulou |
| author_sort | Paraskevi Detopoulou |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Cancer treatments can adversely influence body weight status, body composition, phase angle (PhA), and resting metabolic rate (RMR), which could possibly affect disease course. Τhe aim was to assess differences in body composition, PhA, RMR, and related parameters in non-small-cell lung cancer (NSCLC) patients after treatment. <i>Methods</i>: The sample consisted of 82 NSCLC (stage IV) male patients (chemotherapy (C) 15.7%; immunotherapy (I) 13.3%; C + I 25.3%; (C) + radiotherapy (R) 22.9 %; and other 15.5%). Body weight and body composition, PhA, RMR, oxygen consumption (VO<sub>2</sub>), ventilation rate, and diet were assessed at baseline and at 3 months after initiation of therapy. <i>Results</i>: Reductions in PhA, RMR, VO<sub>2</sub>, ventilation rate, and intracellular water were observed at follow up. Weight loss was evident for 45% of patients who also had a reduction in lean body mass. In the group under C, lean mass was reduced at follow up (55.3 ± 11.53 vs. 52.4 ± 12.6, <i>p</i> = 0.04) without significant weight changes. In subjects with a low adherence to the Mediterranean diet (MedDietScore < 30), RMR (1940 ± 485 vs. 1730 ± 338 Kcal, <i>p</i> = 0.001), VO<sub>2</sub> (277.1 ± 70.2 vs. 247 ± 49.1 mL/min, <i>p</i> = 0.001), and ventilation rate (10.1 ± 2.28 vs. 9. ± 2 2.2 L/min, <i>p</i> = 0.03) were significantly reduced. The changes in body weight were positively related to % of change in fat mass (rho = 0.322, <i>p</i> = 0.003) and absolute lean mass change (rho = 0.534, <i>p</i> < 0.001) and negatively associated with % of change in total body water (rho = −0.314, <i>p</i> = 0.004) (Spearman correlation coefficients). <i>Conclusions</i>: In conclusion, cancer therapy related to reductions in PhA and RMR, while lean mass reduction may be related to the type of treatment. Our results emphasize the importance of a more holistic nutritional and body composition assessment beyond body weight, to better address patients’ needs in clinical practice. |
| first_indexed | 2024-03-09T16:07:40Z |
| format | Article |
| id | doaj.art-e9cd7791ac4749979ca25711976ce4d3 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T16:07:40Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e9cd7791ac4749979ca25711976ce4d32023-11-24T16:32:35ZengMDPI AGMedicina1010-660X1648-91442022-12-015812177910.3390/medicina58121779Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing TherapyParaskevi Detopoulou0Theodora Tsiouda1Maria Pilikidou2Foteini Palyvou3Eirini Tsekitsidi4Maria Mantzorou5Persefoni Pezirkianidou6Krystallia Kyrka7Spyridon Methenitis8Gavriela Voulgaridou9Pavlos Zarogoulidis10Rena Oikonomidou11Dimitris Matthaios12Κonstantinos Porpodis13Dimitrios Giannakidis14Sousana K. Papadopoulou15Department of Clinical Nutrition, General Hospital Korgialenio Benakio, 57889 Athens, GreecePulmonary-Oncology Department, ‘Theageneio’ Cancer Hospital, 54639 Thessaloniki, GreeceDepartment of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, GreeceDepartment of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, GreeceDepartment of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, GreeceDepartment of Food Science and Nutrition, University of Aegean, 81100 Lemnos, GreecePulmonary-Oncology Department, ‘Theageneio’ Cancer Hospital, 54639 Thessaloniki, GreecePulmonary-Oncology Department, ‘Theageneio’ Cancer Hospital, 54639 Thessaloniki, GreeceSports Performance Laboratory, School of Physical Education and Sports Science, National and Kapodistrian University of Athens, 57668 Athens, GreeceDepartment of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, GreecePulmonary Department, General Clinic Euromedica Private Hospital, 54645 Thessaloniki, GreeceHealth Center of Evosmos, 56224 Thessaloniki, GreeceOncology Department, General Hospital of Rhodes, 86775 Rhodes, GreecePulmonary Department, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece1st Department of Surgery, Attica General Hospital “Sismanogleio–Amalia Fleming”, 15126 Athens, GreeceDepartment of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, Greece<i>Background and Objectives</i>: Cancer treatments can adversely influence body weight status, body composition, phase angle (PhA), and resting metabolic rate (RMR), which could possibly affect disease course. Τhe aim was to assess differences in body composition, PhA, RMR, and related parameters in non-small-cell lung cancer (NSCLC) patients after treatment. <i>Methods</i>: The sample consisted of 82 NSCLC (stage IV) male patients (chemotherapy (C) 15.7%; immunotherapy (I) 13.3%; C + I 25.3%; (C) + radiotherapy (R) 22.9 %; and other 15.5%). Body weight and body composition, PhA, RMR, oxygen consumption (VO<sub>2</sub>), ventilation rate, and diet were assessed at baseline and at 3 months after initiation of therapy. <i>Results</i>: Reductions in PhA, RMR, VO<sub>2</sub>, ventilation rate, and intracellular water were observed at follow up. Weight loss was evident for 45% of patients who also had a reduction in lean body mass. In the group under C, lean mass was reduced at follow up (55.3 ± 11.53 vs. 52.4 ± 12.6, <i>p</i> = 0.04) without significant weight changes. In subjects with a low adherence to the Mediterranean diet (MedDietScore < 30), RMR (1940 ± 485 vs. 1730 ± 338 Kcal, <i>p</i> = 0.001), VO<sub>2</sub> (277.1 ± 70.2 vs. 247 ± 49.1 mL/min, <i>p</i> = 0.001), and ventilation rate (10.1 ± 2.28 vs. 9. ± 2 2.2 L/min, <i>p</i> = 0.03) were significantly reduced. The changes in body weight were positively related to % of change in fat mass (rho = 0.322, <i>p</i> = 0.003) and absolute lean mass change (rho = 0.534, <i>p</i> < 0.001) and negatively associated with % of change in total body water (rho = −0.314, <i>p</i> = 0.004) (Spearman correlation coefficients). <i>Conclusions</i>: In conclusion, cancer therapy related to reductions in PhA and RMR, while lean mass reduction may be related to the type of treatment. Our results emphasize the importance of a more holistic nutritional and body composition assessment beyond body weight, to better address patients’ needs in clinical practice.https://www.mdpi.com/1648-9144/58/12/1779lung cancerdietphase anglebody compositionchemotherapyradiotherapy |
| spellingShingle | Paraskevi Detopoulou Theodora Tsiouda Maria Pilikidou Foteini Palyvou Eirini Tsekitsidi Maria Mantzorou Persefoni Pezirkianidou Krystallia Kyrka Spyridon Methenitis Gavriela Voulgaridou Pavlos Zarogoulidis Rena Oikonomidou Dimitris Matthaios Κonstantinos Porpodis Dimitrios Giannakidis Sousana K. Papadopoulou Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy Medicina lung cancer diet phase angle body composition chemotherapy radiotherapy |
| title | Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy |
| title_full | Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy |
| title_fullStr | Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy |
| title_full_unstemmed | Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy |
| title_short | Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy |
| title_sort | changes in body weight body composition phase angle and resting metabolic rate in male patients with stage iv non small cell lung cancer undergoing therapy |
| topic | lung cancer diet phase angle body composition chemotherapy radiotherapy |
| url | https://www.mdpi.com/1648-9144/58/12/1779 |
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