The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice
Abstract Introduction It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions. Methods Our study examined the effect of varying the timing of high‐fat diet (HFD) consumption on...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12173 |
| _version_ | 1817975402539253760 |
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| author | Anna Amelianchik Jonathan Merkel Premkumar Palanisamy Shigeru Kaneki Emily Hyatt Erin H. Norris |
| author_facet | Anna Amelianchik Jonathan Merkel Premkumar Palanisamy Shigeru Kaneki Emily Hyatt Erin H. Norris |
| author_sort | Anna Amelianchik |
| collection | DOAJ |
| description | Abstract Introduction It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions. Methods Our study examined the effect of varying the timing of high‐fat diet (HFD) consumption on AD‐related pathology and cognition in transgenic Tg6799 AD mice. Results HFD feeding starting at or before 3 months of age, prior to severe AD pathology, had protective effects in AD mice: reduced extracellular amyloid beta (Aβ) deposition, decreased fibrinogen extravasation into the brain parenchyma, and improved cognitive function. However, delaying HFD consumption until 6 months of age, when AD pathology is ubiquitous, reduced these protective effects in AD mice. Discussion Overall, we demonstrate that the timeline of HFD consumption may play an important role in how dietary fats affect AD pathogenesis and cognitive function. |
| first_indexed | 2024-04-13T21:48:32Z |
| format | Article |
| id | doaj.art-e9ce13db0c7f421fb088c4a980426dcf |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-13T21:48:32Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-e9ce13db0c7f421fb088c4a980426dcf2022-12-22T02:28:29ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372021-01-0171n/an/a10.1002/trc2.12173The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in miceAnna Amelianchik0Jonathan Merkel1Premkumar Palanisamy2Shigeru Kaneki3Emily Hyatt4Erin H. Norris5Patricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USAPatricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USAPatricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USAPatricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USAPatricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USAPatricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USAAbstract Introduction It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions. Methods Our study examined the effect of varying the timing of high‐fat diet (HFD) consumption on AD‐related pathology and cognition in transgenic Tg6799 AD mice. Results HFD feeding starting at or before 3 months of age, prior to severe AD pathology, had protective effects in AD mice: reduced extracellular amyloid beta (Aβ) deposition, decreased fibrinogen extravasation into the brain parenchyma, and improved cognitive function. However, delaying HFD consumption until 6 months of age, when AD pathology is ubiquitous, reduced these protective effects in AD mice. Discussion Overall, we demonstrate that the timeline of HFD consumption may play an important role in how dietary fats affect AD pathogenesis and cognitive function.https://doi.org/10.1002/trc2.12173Alzheimer's diseaseamyloid betafibrinogenhigh‐fat dietobesity |
| spellingShingle | Anna Amelianchik Jonathan Merkel Premkumar Palanisamy Shigeru Kaneki Emily Hyatt Erin H. Norris The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease amyloid beta fibrinogen high‐fat diet obesity |
| title | The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice |
| title_full | The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice |
| title_fullStr | The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice |
| title_full_unstemmed | The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice |
| title_short | The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice |
| title_sort | protective effect of early dietary fat consumption on alzheimer s disease related pathology and cognitive function in mice |
| topic | Alzheimer's disease amyloid beta fibrinogen high‐fat diet obesity |
| url | https://doi.org/10.1002/trc2.12173 |
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