Increased METTL3-mediated m6A methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure

Increased METTL3-mediated m6A methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure

Abstract Background Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N6-methyladenosine (m6A) has been demonstrated to be involved in various biological processes, its potential role in...

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Bibliographic Details
Main Authors: Pingping Xue, Wenbo Zhou, Wenqiang Fan, Jianya Jiang, Chengcai Kong, Wei Zhou, Jianmei Zhou, Xiaoyang Huang, Haiyan Yang, Qian Han, Bin Zhang, Lingyun Xu, Bin Yu, Li Chen
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Reproductive Biology and Endocrinology
Subjects:
METTL3
m6A methylation
HOXA10
embryo implantation
recurrent implantation failure
Online Access:https://doi.org/10.1186/s12958-021-00872-4

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